Malnutrition, encompassing both undernutrition and overnutrition, is prevalent among patients with chronic kidney disease (CKD). It is influenced by a myriad of factors, including dietary restrictions, metabolic irregularities, inflammation, and comorbidities. It leads to increased morbidity, mortality, and diminished quality of life. In children, malnutrition hinders growth and development, particularly during infancy and early childhood. This article provides a comprehensive overview of current terminologies delineating undernutrition and overnutrition in CKD, and discusses age-specific nutritional assessment tools. It delves into macro- and micronutrient prescriptions tailored for both adults and children with CKD, emphasizing special considerations such as low and very low protein diets. A focus on the nutrient content of Indian foods is also provided, alongside available nutritional supplements, with insights into enteral feeding and the fortification of feeds in young children. Distinctive nuances in nutritional therapy between adults and children are elucidated throughout the article, drawing upon established guidelines, including Kidney Disease Outcomes and Quality Initiative (KDOQI) 2009 and 2020 and KDIGO CKD 2024 guidelines as well as Pediatric Renal Nutrition Task Force clinical practice recommendations, to inform dietary management strategies for individuals across the lifespan living with CKD.
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http://dx.doi.org/10.25259/IJN_222_2024 | DOI Listing |
Ann Work Expo Health
March 2025
Department of Environmental and Occupational Health (EOH), Colorado School of Public Health, University of Colorado Anschutz Campus, 13001 E. 17th Place, Mail Stop B119, Aurora, CO 80045, United States.
Background: There is an international epidemic of chronic kidney disease of unknown cause (CKDu) in agricultural working populations. Particulate air pollution is a likely contributing factor in populations at risk for CKDu, but there is little personal breathing zone data for these workers.
Methods: We collected 1 to 3 personal breathing zone particulate matter <5 microns (PM5) gravimetric measurements in 143 male sugarcane harvesters over 2 seasons and concurrent ambient samples using personal sampling pumps and cyclone inlets as a sampling train.
Liver Int
April 2025
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease globally. MASLD is a multisystem disease where metabolic dysfunction plays a key role in the development of MASLD and its most relevant liver-related morbidities and extrahepatic complications, such as cardiovascular disease, chronic kidney disease and certain types of extrahepatic cancers. Among the least examined MASLD-related extrahepatic complications, an ever-increasing number of observational studies have reported a positive association between MASLD and the risk of serious bacterial infections (SBI) requiring hospital admission.
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March 2025
Fondazione CNR-Regione Toscana G Monasterio, Via G. Moruzzi 1, 56124 Pisa, Italy.
In recent years, new drugs for the treatment of type 2 diabetes (T2D) have been proposed, including glucagon-like peptide 1 (GLP-1) agonists or sodium-glucose cotransporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors. Over time, some of these agents (in particular, GLP-1 agonists and SGLT2 inhibitors), which were initially developed for their glucose-lowering actions, have demonstrated significant beneficial pleiotropic effects, thus expanding their potential therapeutic applications. This review aims to discuss the mechanisms, pleiotropic effects, and therapeutic potential of GLP-1, DPP-4, and SGLT2, with a particular focus on their cardiorenal benefits beyond glycemic control.
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March 2025
Renal Division, Department of Medicine IV, Ludwig-Maximilians-University (LMU) Hospital, Ludwig-Maximilians-University (LMU), 80336 Munich, Germany.
A20/Tnfaip3, an early NF-κB response gene and key negative regulator of NF-κB signaling, suppresses proinflammatory responses. Its ubiquitinase and deubiquitinase activities mediate proteasomal degradation within the NF-κB pathway. This study investigated the involvement of A20 signaling alterations in podocytes in the development of kidney injury.
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March 2025
Departement of Rheumatology, Erasme-HUB Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Tubulointerstitial hypoxia is a key factor for lupus nephritis progression to end-stage renal disease. Numerous aquaporins (AQPs) are expressed by renal tubules and are essential for their proper functioning. The aim of this study is to characterize the tubular expression of AQP1, AQP2 and AQP3, which could provide a better understanding of tubulointerstitial stress during lupus nephritis.
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