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| http://dx.doi.org/10.1002/hpja.70027 | DOI Listing |
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Families' experiences and perspectives on the early use of powered mobility in children with spinal muscular atrophy type I in the natural context.
Disabil Rehabil Assist Technol
March 2025
Faculty of Physiotherapy and Nursing. Department of Nursing, Physiotherapy and Occupational Therapy, Universidad de Castilla-La Mancha, Toledo, Spain.
Purpose: To describe the experiences of parents who used powered mobility in children with Spinal Muscular Atrophy, SMA type I,at an early age in the natural context like a family-centered program, using inductive qualitative content analysis.
Materials And Methods: This qualitative study was embedded within a single-blinded randomized waiting list controlled clinical trial, which involved 16 children with SMA type I. This study specifically explores the experiences of the 9 parents whose children participated in the intervention group and completed the training.
Integrated multi-omics characterization of neuroblastoma with bone or bone marrow metastasis.
Genes Dis
May 2025
Department of Pediatric Surgical Oncology, The Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing 400014, China.
The pathogenesis of neuroblastoma with bone or bone marrow metastasis (NB-BBM) and its complex immune microenvironment remain poorly elucidated, hampering the advancement of effective risk prediction for BBM and limiting therapeutic strategies. Feature recognition of 142 paraffin-embedded hematoxylin-eosin-stained tumor section images was conducted using a Swin-Transformer for pathological histology to predict NB-BBM occurrence. Single-cell transcriptomics identified a tumor cell subpopulation (NB3) and two tumor-associated macrophage (TAM) subpopulations (SPP1 TAMs and IGHM TAMs) closely associated with BBM and highlighted transketolase (TKT) as a key molecular marker for metastatic progression in NB.
View Article and Find Full Text PDFIncidence of food allergic reactions among adolescents engaged in food allergy management.
Ann Allergy Asthma Immunol
March 2025
University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Background: While fatal food-induced anaphylaxis is rare, adolescence is the period of highest risk. However, we lack strong estimates of the incidence of food allergic reactions among adolescents.
Objective: To estimate the incidence of food allergic reactions and anaphylactic reactions among adolescents with food allergy who have a prescription for epinephrine.
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Plastic and Reconstructive Surgery, Hull University Teaching Hospitals National Health Service (NHS) Trust, Hull, GBR.
Burn injuries in the paediatric population are common and account for a substantial proportion of hospital attendances, leading to a growing focus on optimising wound care to enhance healing, reduce discomfort and minimise the need for frequent dressing changes. Traditional dressings for superficial burns in children have inherent limitations that may hinder these goals. Biobrane (Dow Hickman/Bertek Pharmaceuticals, Sugar Land, TX), a semi-permeable silicone device embedded with a nylon mesh and a porcine-derived collagen matrix, offers a promising alternative with advantages such as improved wound healing, reduced pain and fewer dressing changes.
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Health Promot J Austr
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Equity, Primary Care, Implementation and Community (EPIC) Research Unit, Monash University, Melbourne, Victoria, Australia.
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