A technological approach for direct glass structuring is presented by exploiting electron-beam-induced defect generation utilizing a conventional scanning electron microscope (SEM). The structuring process is assumed to be linked to electron-beam-induced ion migration and allows to create structures of several hundred nanometers in depth. It is demonstrated that the structuring can be realized in literally any SEM, which thus enables a comparatively simple implementation in support of a broad field of applications. The experiments are realized using electron energies of 5 to 15 keV in combination with different kinds of glasses, such as fused silica and ultra-low expansion glass, that are equipped with a charge dissipation top-layer. By controlling the beam trajectory at the surface and the electron beam parameters, freeform structuring, structure arrays, direct embedding of metal structures into the glass surface, and beam-defined three-level patterning are realized. The shown electron beam-based glass structuring extends therefore the current possibilities in a complementary manner, enabling further fabrication strategies and direct structuring even of fragile, 3D-structured surfaces.
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http://dx.doi.org/10.1002/smtd.202401671 | DOI Listing |
Mol Pharm
March 2025
Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Polyamorphism in organic molecules is a poorly understood and controversial phenomenon related to amorphous materials. Although very few studies, including our own, have demonstrated the existence of polyamorphism in drug molecules, this solid-state phenomenon is still very elusive and the investigation of its occurrence in other drugs is fundamental to understand its formation. Indomethacin (IND) has been recently discussed in the literature as a potential drug exhibiting polyamorphism.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
March 2025
Institute of Physics, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
Low-energy excitations play a key role in all condensed-matter systems, yet there is limited understanding of their nature in glasses, where they correspond to local rearrangements of groups of particles. Here, we introduce an algorithm to systematically uncover these excitations up to the activation energy scale relevant to structural relaxation. We use it in a model system to measure the density of states on a scale never achieved before, confirming that this quantity shifts to higher energy under cooling, precisely as the activation energy does.
View Article and Find Full Text PDFJ Phys Chem B
March 2025
Department of Chemistry, University of Rome Sapienza, Rome 00185, Italy.
We present a structural characterization of a low-transition-temperature mixture (LTTM), consisting of thymol and carvacrol, at an equimolar ratio. Carvacrol and thymol are natural regioisomers of terpenes. When combined at an equimolar ratio, they form a liquid mixture at room temperature, with supercooling capability and glass transition at ca.
View Article and Find Full Text PDFMater Horiz
March 2025
School of Applied & Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India.
Lead halide perovskites are widely recognized for their exceptional defect tolerance, setting the benchmark for high-performance optoelectronic applications. Conversely, low-toxicity perovskite-inspired materials (PIMs) typically exhibit suboptimal optoelectronic performance, primarily due to their intrinsic susceptibility to defects. In this study, we address this limitation by exploring the effects of halide vacancies in PIMs through the synthesis of non-stoichiometric CsBiBrI microcrystals (MCs) with a trigonal crystal structure, incorporating iodine vacancies.
View Article and Find Full Text PDFSoft Matter
March 2025
Institute of Electronic Structure & Laser, FORTH, Heraklion, 70013, Greece.
The cage concept, a central microscopic mechanism for glassy dynamics, has been utilized in concentrated colloidal suspensions to describe a number of phenomena. Here, we probe the evolution of cage formation and shear elasticity with increasing volume fraction in hard sphere suspensions, with emphasis on the short-time dynamics. To this end, we utilize linear viscoelastic (LVE) measurements, by means of conventional rotational rheometers and a home-made HF piezo-rheometer, to probe the dynamic response over a broad range of volume fractions up to the very dense glassy regime in proximity to random close packing.
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