Ultrasound is an indispensable technology in the biomedical field. With the continuous integration and development of ultrasound medical technology, its potential application value in disease diagnosis and treatment has become increasingly prominent. As the technical core, novel multifunctional ultrasound theranostic agents have been the main focus of research. Here, we summarized various types of multifunctional ultrasound agents, presented their latest applications in important areas, and discussed subsequent research priorities. We hope that with the combination of new technologies, multifunctional ultrasound agents can play a greater role in the diagnosis and treatment of diseases, further promoting the extensive and in-depth development of ultrasound medical technology.
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http://dx.doi.org/10.2174/0113892010352224250304080131 | DOI Listing |
Chemistry
March 2025
Northwestern Polytechnical University, Institute of Medical Research, 127 West Youyi Road, 710072, Xi'an, CHINA.
The G-quadruplex (G4) is an important diagnostic and therapeutic target in cancers, but the development of theranostic probes for subcellular G4s remains challenging. In this work, we report three G4-targeted theranostic probes by conjugating a pyridostatin-derived G4 ligand to G4-specific iridium(III) complexes with desirable photophysical properties. These probes showed specifically enhanced luminescence to mitochondrial G4 in triple negative breast cancer (TNBC) cells.
View Article and Find Full Text PDFCurr Pharm Biotechnol
March 2025
Postdoctoral Research Station, School of Microelectronics and Communication Engineering, Chongqing University, Chongqing 400044, P.R. China.
Ultrasound is an indispensable technology in the biomedical field. With the continuous integration and development of ultrasound medical technology, its potential application value in disease diagnosis and treatment has become increasingly prominent. As the technical core, novel multifunctional ultrasound theranostic agents have been the main focus of research.
View Article and Find Full Text PDFBiomaterials
March 2025
Department of Chemistry, Korea University, Seoul 02841, Korea. Electronic address:
Small molecule-based multifunctional optical diagnostic materials have garnered considerable interest due to their highly customizable structures, tunable excited-state properties, and remarkable biocompatibility. We herein report the synthesis of a multifaceted photosensitizer, PPQ-CTPA, which exhibits exceptional efficacy in generating Type I reactive oxygen species (ROS) and thermal energy under near-infrared-II (NIR-II, >1000 nm) laser excitation at 1064 nm, thereby combining photodynamic therapy (PDT) and photothermal therapy (PTT) functionalities. To enhance therapeutic efficacy, we engineered lonidamine (LND) by conjugating it with triphenylphosphonium (TPP) cations, producing LND-TPP.
View Article and Find Full Text PDFInt J Biol Macromol
March 2025
State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, China; State Key Laboratory of Marine Resource Utilization in the South China Sea, School of Materials Science and Engineering, Hainan University, Haikou 570228, China; Collaborative Innovation Center of One Health, Key Laboratory of Biomedical Engineering of Hainan Province, Hainan University, Haikou 570228, China. Electronic address:
Glioblastoma is the most aggressive and heterogeneous astrocytic tumor, with its intracranial location limiting the efficacy of conventional therapies. This study presents the synthesis of a multifunctional nanocomplex utilizing borophene nanosheets (B NSs) as a substrate. Gold nanoparticles (Au NPs) are modified onto the surface of B NSs to create Schottky heterojunctions (BAu).
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2025
Department of Biomedical and Engineering, School of Medicine, Shenzhen University, Shenzhen 518061, China.
Stacked semiconducting nanosheets (SSNs), which feature strong in-plane covalent bonds but weak van der Waals (vdWs) interactions between adjacent layers, hold substantial promise in next-generation, printable, and flexible devices. Among them, SSN-based transistors with high current multiplication offer significant potential for large-area, high-integration electronics and biomedical applications. However, the three-terminal configuration of the transistor inevitably increases the process step and power unit.
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