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Mediation Analysis of Gut Microbiota and Plasma Metabolites in Asthma Pathogenesis Using Mendelian Randomization.
J Asthma
March 2025
Department of Emergency, Wujin Hospital Affiliated with Jiangsu University and Wujin Clinical College of Xuzhou Medical University, Changzhou, 213017, Jiangsu, China.
Asthma is a prevalent chronic respiratory condition with multifactorial pathogenesis. Emerging evidence suggests that gut microbiota and their metabolites influence asthma risk. This study explores the mediation effects of plasma metabolites between gut microbiota and asthma using Mendelian randomization (MR) analysis.
View Article and Find Full Text PDFHow Families Manage the Home Environment for Young People With Asthma and Allergic Sensitisation: A Qualitative Study.
Pediatr Pulmonol
March 2025
Asthma UK Centre for Applied Research, USHER Institute, University of Edinburgh, Edinburgh, UK.
Background And Aim: Children and young people (CYP) with severe, sub-optimally controlled asthma and co-existing allergic senitization to indoor aeroallergens, such as pet dander and house dust mite (HDM), would likely benefit from reduced allergen exposure. Multiple allergen remediation interventions exist and are often suggested to families in secondary care asthma clinics in the United Kingdom. Evidence suggests remediation uptake is low or partial but there is sparse evidence to explain why.
View Article and Find Full Text PDFCohort multiple randomized controlled trial in pediatric asthma to assess the long- and short-term effects of eHealth interventions: protocol of the CIRCUS study.
Ther Adv Respir Dis
March 2025
Pediatric Department, Medisch Spectrum Twente, Enschede, The Netherlands.
Background: Asthma is one of childhood's most prevalent chronic conditions significantly impacting the quality of life. Current asthma management lacks real-time, objective, and longitudinal monitoring reflected by a high prevalence of uncontrolled asthma. Long-term home monitoring promises to establish new clinical endpoints for timely anticipation.
View Article and Find Full Text PDFDifferent Modalities in the Management of Post-COVID-19 Olfactory Dysfunction.
Indian J Otolaryngol Head Neck Surg
January 2025
Otorhinolaryngology Department, Faculty of Medicine, Benha University, Benha, Qalyubia Egypt.
SARS-CoV-2 infection may lead to olfactory dysfunctions affecting patients' quality of life. Despite various ongoing studies, solid evidence supporting therapies, especially for COVID-19-related olfactory dysfunction, remains scarce. To assess nasal steroid, nasal vitamin A, and intranasal theophylline as treatment options for post-COVID-19 olfactory dysfunction.
View Article and Find Full Text PDFGeniposidic acid inhibits OVA-induced asthma by suppressing allergic airway inflammation and regulating gut microbiota.
Front Immunol
March 2025
Department of Gynecology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Asthma is a serious chronic inflammatory disease of the respiratory system. In this study, we aimed to explore the role of geniposidic acid (GPA) in ovalbumin (OVA)-induced asthma in mice and to clarify its underlying mechanism. The mice were divided into control group, OVA group, OVA+GPA (12.
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