Objectives: To explore the effect of transcutaneous auricular vagus nerve stimulation (taVNS) combined with patient-controlled intravenous analgesia (PCIA) on postoperative pain in patients undergoing total knee arthroplasty (TKA).
Methods: A total of 140 patients with TKA were randomly divided into the taVNS group (=70, with 5 dropped-out) and the sham stimulation group (=70, with 6 dropped-out). The taVNS group received taVNS at the left ear conchae combined with PCIA treatment, while the sham stimulation group received sham taVNS at the left ear conchae combined with PCIA treatment. The time-weighted average (TWA) pain score, visual analogue scale (VAS) score of 1-7 days after surgery, the occurrence of adverse reactions such as nausea, vomiting, skin pruritus, drowsiness, respiratory depression, and the number of PCIA pump compressions within 48 hours after surgery were observed and compared between the 2 groups. The Beck Anxiety Inventory (BAI) scores, Bake Depression Inventory (BDI) scores, and Pittsburgh Sleep Quality Index (PSQI) scores were obtained on the day before surgery and 7 days after surgery.
Results: Compared with the sham stimulation group, the TWA pain score of the taVNS group was significantly decreased at the 7 day postoperatively (<0.01), and the VAS scores of the taVNS group were significantly lower than those of the sham stimulation group on postoperative days 3, 4, and 5 (<0.001, <0.01, <0.05), with no statistical significance in VAS scores on postoperative days 1, 2, 6, and 7. Compared with the sham stimulation group, the incidence of nausea and the number of PCIA pump compressions within 48 hours after surgery in the taVNS group was significantly decreased (<0.05). There was no statistical significance in the differences between the BDI, BAI, and PSQI scores before and after surgery in both groups. PSQI scores in the sham stimulation group and taVNS group were significantly lower than those in the same group 1 day before surgery (<0.01, <0.001).
Conclusions: The taVNS combined with PCIA can reduce postoperative pain, the incidence of nausea, and the opioid dosage in TKA patients.
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Impact of transcutaneous auricular vagus nerve stimulation on postoperative pain in patients undergoing perianal surgery: a randomized trial.
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Objectives: To explore the effect of transcutaneous auricular vagus nerve stimulation (taVNS) combined with patient-controlled intravenous analgesia (PCIA) on postoperative pain in patients undergoing total knee arthroplasty (TKA).
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