Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pmn.2025.02.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Induction of mitochondrial damage via the CREB3L1/miR-34c/COX1 axis by porcine epidemic diarrhea virus infection facilitates pathogenicity.
J Virol
March 2025
College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Porcine epidemic diarrhea virus (PEDV) is a primary cause of viral diarrhea in neonatal piglets, leading to substantial economic losses in the swine industry globally. It primarily targets epithelial cells of the small intestine, compromising intestinal function and resulting in the death of affected animals. As mitochondria are essential for maintaining gut health, this study investigates the effects of PEDV infection on mitochondrial function in small intestinal epithelial cells and its subsequent impacts.
View Article and Find Full Text PDFDo Treatment Choices by Artificial Intelligence Correspond to Reality? Retrospective Comparative Research with Necrotizing Enterocolitis as a Use Case.
Med Decis Making
March 2025
Department of Surgery, Division of Pediatric Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
BackgroundIn cases of surgical necrotizing enterocolitis (NEC), the choice between laparotomy (LAP) or comfort care (CC) presents a complex, ethical dilemma. A behavioral artificial intelligence technology (BAIT) decision aid was trained on expert knowledge, providing an output as " percentage of experts advise laparotomy for this patient." This retrospective study aims to compare this output to clinical practice.
View Article and Find Full Text PDFMeconium ileus (MI) is the result of the accumulation of thick, dry, inspissated meconium that creates a bowel blockage, most commonly in the terminal ileum. These pockets of meconium prevent passage of stool beyond the point of obstruction, which leads to distention of the proximal bowel, bowel wall thickening, and distal microcolon. Occurring most commonly (90%) in conjunction with cystic fibrosis (CF), the occurrence of MI without CF is rare.
View Article and Find Full Text PDFIdentification of potential biomarkers associated with oxidative stress in the pathogenesis of pre-eclampsia.
Medicine (Baltimore)
March 2025
Department of Gynecology and Obstetrics, Haidian Maternal and Child Health Hospital, Beijing, China.
Pre-eclampsia (PE) is a multisystem pregnancy disorder characterized by placental and maternal endothelial dysfunction, and affects approximately 5% to 7% of pregnancies worldwide, leading to significant maternal and neonatal morbidity and mortality. Mounting evidence indicates that placental oxidative stress (OS) plays a critical role in the pathogenesis of PE. However, the specific mechanisms associated with OS during the occurrence and progression of PE remain largely unknown.
View Article and Find Full Text PDFAmikacin dosing in neonates: evaluation of target attainment using a simplified and complex pharmacokinetic model-derived dosing regimen in clinical practice.
Antimicrob Agents Chemother
March 2025
Department of Pharmacy & Clinical Pharmacology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Amikacin is frequently used for the treatment of neonatal sepsis. The Dutch Pediatric Formulary recommends a complex pharmacokinetic (PK) model-derived dosing regimen, which consists of dosing categories based on postnatal age and weight that results in adequate PK/pharmacodynamic (PK/PD) target attainment. However, a simplified dosing regimen may be easier to apply in clinical practice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!