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The Effect of Protein Intake on Bone Disease, Kidney Disease, and Sarcopenia: A Systematic Review.
Curr Dev Nutr
March 2025
Minnesota Evidence-Based Practice Center, School of Public Health, University of Minnesota, Minneapolis, MN, United States.
Background: Protein is essential for optimal growth, function, and maintenance of health. Its impact on bone, kidney health, and sarcopenia progression remains debated.
Objectives: This review examines the association between dietary protein intake and the risk of bone disease, kidney disease, and sarcopenia to inform protein dietary reference intake updates.
Calcium phosphate-based anti-infective bone cements: recent trends and future perspectives.
Front Pharmacol
February 2025
Department of Orthopaedics, Second Affiliated Hospital, Air Force Medical University, Xi'an, China.
Bone infection remains a challenging condition to fully eradicate due to its intricate nature. Traditional treatment strategies, involving long-term and high-dose systemic antibiotic administration, often encounter difficulties in achieving therapeutic drug concentrations locally and may lead to antibiotic resistance. Bone cement, serving as a local drug delivery matrix, has emerged as an effective anti-infective approach validated in clinical settings.
View Article and Find Full Text PDFCargo-less Nanoparticles Prevent Bone Loss in Periodontitis and Peri-implantitis.
J Dent Res
March 2025
Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Periodontal and peri-implant diseases are a significant public health problem worldwide, resulting in the destruction of the supporting bone. These bone defects can cause esthetic problems, increased relapse rate, and eventually tooth loss. The etiology of periodontal disease involves an influx of innate immune cells (neutrophils and monocytes) and upregulation of local inflammatory cytokines in the gingiva.
View Article and Find Full Text PDFInsights on the Role of Sialic Acids in Acute Lymphoblastic Leukemia in Children.
Int J Mol Sci
March 2025
Department of Life Science, Graduate School, CHA University, Seongnam-si 13488, Gyeonggi-do, Republic of Korea.
Sialic acids serve as crucial terminal sugars on glycoproteins or glycolipids present on cell surfaces. These sugars are involved in diverse physiological and pathological processes through their interactions with carbohydrate-binding proteins, facilitating cell-cell communication and influencing the outcomes of bacterial and viral infections. The role of hypersialylation in tumor growth and metastasis has been widely studied.
View Article and Find Full Text PDFFatty Degenerative Osteonecrosis of the Jaw: Bridging Molecular Insights and Clinical Practice-A Scoping Review.
Int J Mol Sci
February 2025
Department of Dental Surgery, Faculty of Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland.
Fatty degenerative osteonecrosis of the jaw (FDOJ) is a chronic, aseptic inflammatory condition that is characterized by molecular disruptions in bone metabolism and necrotic bone marrow within the jawbone cavities. In contrast to the overt clinical signs typically observed in osteopathies, FDOJ frequently presents with a "silent inflammation" phenotype. The electronic databases PubMed, Scopus, and Embase were searched using appropriate search terms, and the methodology was performed according to PRISMA-ScR guidelines.
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