It was found out that when the patients with atherosclerosis are orally administered ubiquinone Q (CoQ), oxidation (lipid hydroperoxide content) of the low-density lipoprotein (LDL) particles sharply decreases, which confirms important role of this natural antioxidant in protecting LDL particles from free radical oxidation . Influence of the lipophilic natural antioxidants ubiquinol Q (CoQH) and α-tocopherol (α-TOH) on the kinetic parameters of Cu-induced free radical oxidation of LDL particles was investigated. In this model system, possible synergism of the antioxidant action of CoQH and α-TOH has been shown. Putative mechanisms of bioregeneration of lipophilic antioxidants in LDL particles, including regeneration of α-TOH from the tocopheroxyl radical (α-TO) with participation of CoQH and/or ascorbate, are discussed.
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