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Statins as an Adjunctive Antithrombotic Agent in Thrombotic Antiphospholipid Syndrome: Mechanisms and Clinical Implications.
Cells
February 2025
Department of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.
The thrombotic physiopathology of antiphospholipid syndrome (APS) is complex, heterogeneous, and dynamic. While venous thromboembolism (VTE) is the most common initial presentation, arterial thrombotic events (ATE) become more frequent in advanced stages and are associated with high morbidity and mortality. Despite the use of oral anticoagulants (OACs), thrombotic APS remains associated with a high risk of recurrent thrombosis.
View Article and Find Full Text PDFEfficacy and Safety of Chemical Venous Thromboembolism Prophylaxis in Spine Trauma Patients: A Systematic Review and Meta-analysis Comparing Anticoagulant Types.
Clin Spine Surg
March 2025
Department of Orthopedics, Beth Israel Deaconess Medical Center, Harvard Medical School.
Study Design: Systematic review and meta-analysis.
Objective: To determine whether venous thromboembolism (VTE) prophylaxis is necessary after spine trauma and to assess the efficacy and safety profiles of anticoagulation agents.
Summary Of Background Data: Venous stasis, endothelial disruption, hypercoagulability, and orthopedic injury in spine trauma predispose 12%-64% of patients to deep vein thrombosis (DVT).
Pulmonary Embolism as a Cause of Death in Lung Transplant Recipients: Data From a Nationwide Registry.
Pulm Circ
January 2025
Thoracic Medicine and Surgery, Temple University Hospital Philadelphia Pennsylvania USA.
Pulmonary embolism (PE) is a leading cause of mortality in lung transplant recipients, with early cases associated with particularly poor outcomes. Identified risk factors include elevated BMI, renal dysfunction, ABO mismatch, donor malignancy, and specific immunosuppressive agents. Tailored risk assessments and targeted interventions are essential to mitigating PE-related mortality.
View Article and Find Full Text PDFEnhanced recovery after endoscopic sinus surgery: Establishing comprehensive protocols for improvement of perioperative patient care.
World J Otorhinolaryngol Head Neck Surg
March 2025
Objectives: Enhanced recovery after surgery (ERAS) protocols for endoscopic sinus surgery (ESS) have not been widely implemented, and a critical review of ERAS recommendations and a comprehensive analysis of the supporting literature has not been undertaken. We describe an ESS ERAS protocol including key perioperative interventions for patients undergoing ESS and assess the available evidence.
Data Sources: A search was conducted of all relevant ERAS literature in otorhinolaryngology, anesthesia, and surgery using Medline (via PubMed), and Scopus.
Evaluating the Merit and Applications of the Caprini Risk Score as a Complication Predictor.
J Reconstr Microsurg
March 2025
Surgery, Cooper University Health Care, Camden, United States.
Background: Venous thromboembolism (VTE) is considered a complication of free flap surgery. Prior studies investigating the use of Caprini Risk Score (CRS) to estimate risk of complications in free flap reconstruction are confounded by small sample sizes, varying surgical sites, and disparate classification of risk. This study evaluates the predictive merit of CRS for complications in free flap reconstructions.
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