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Spectroscopic Study of Methylene Blue Interaction with Coenzymes and its Effect on Tumor Metabolism.
Sovrem Tekhnologii Med
March 2025
Junior Researcher, Laser Biospectroscopy Laboratory, Light-Induced Surface Phenomena Department, Natural Sciences Center; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St., Moscow, 119991, Russia.
Unlabelled: is to study the interaction of methylene blue (MB) with NADH, FADH coenzymes and lactate, and to evaluate a long-term effect of its intravenous or oral introduction on tumor metabolism .
Materials And Methods: The MB interaction with NADH, FADH coenzymes and lactate was studied using absorption spectrophotometry. A long-term effect of MB on tumor metabolism was investigated on a mice model of Ehrlich carcinoma.
Study on the regularity of blood pressure changes in pregnant women and its influencing factors.
BMC Pregnancy Childbirth
March 2025
Department of Anesthesia Surgery, The First Hospital of Hebei Medical University, No. 89 Donggang Road, Yuhua District, Shijiazhuang, 050030, China.
Objective: To explore the patterns and influencing factors of blood pressure changes in pregnant women at different stages of pregnancy.
Method: A retrospective analysis of 445 pregnant women who underwent prenatal examination and delivered at the First Hospital of Hebei Medical University between December 2016 and November 2017. A questionnaire survey was conducted on pre-pregnancy information, and data was collected from pre-pregnancy blood routines, blood lipids, cortisol levels, and other biochemical indicators, as well as blood pressure measurements taken before pregnancy, in early pregnancy, mid-pregnancy, and late pregnancy.
Type of diet has no major influence on inflammatory response in a Saddleback pig model.
Sci Rep
March 2025
Institute of Animal Nutrition, Nutrition Diseases and Dietetics, Leipzig University, Leipzig, Germany.
Fermentable carbohydrates and resulting short-chain fatty acids (SCFAs) received attention via modifying potential on obesity-associated systemic low-grade inflammation. However, their effects on inflammation remain poorly understood. In this study, the anti-inflammatory properties of pectin or inulin supplementation were investigated in an atherogenic-fed pig obesity model.
View Article and Find Full Text PDFp53 activates circASCC3 to repress R-loops and enhance resistance to chemotherapy.
Proc Natl Acad Sci U S A
March 2025
Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
The tumor suppressor p53 can trigger tumor resistance to chemotherapy by facilitating DNA damage repair and maintaining genomic integrity. Here, we report that a p53-induced circular RNA circASCC3 promotes chemotherapeutic resistance by resolving R-loops. Our results reveal that p53 directly activates the transcription of , the host gene of circASCC3.
View Article and Find Full Text PDFLNS8801: An enantiomerically pure agonist of the G protein-coupled estrogen receptor suitable for clinical development.
Cancer Res Commun
March 2025
University of Pennsylvania, Philadelphia, PA, United States.
Estrogen effects in tissue are mediated in part through activation of the surface estrogen receptor GPER, a broadly expressed G protein-coupled receptor that impacts a wide range of normal and pathologic processes, including metabolism, vascular health, inflammation, and cancer. A commonly used synthetic and specific GPER agonist, named G-1, antagonizes tumors by promoting cellular differentiation and enhancing tumor immunogenicity. G-1 is a racemic compound, and since its discovery, the question of whether both enantiomers display agonist activity or the agonist activity resides primarily in a single enantiomer has never been fully resolved.
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