Aspirin nanosensors.

Aspirin, a widely used nonsteroidal anti-inflammatory drug (NSAID), plays a crucial role in the prevention and treatment of various cardiovascular and inflammatory conditions, including its significant application in stroke management. The accurate detection of aspirin in biological and environmental samples is essential for ensuring therapeutic efficacy and safety, particularly in patients at risk of stroke. This review aims to introduce and discuss the recent advancements in aspirin nanosensor technology, highlighting innovative approaches that enhance detection sensitivity and specificity. Traditional methods of aspirin detection often face limitations, including lengthy analysis times, the need for complex sample preparation, and insufficient sensitivity for trace detection. In contrast, the development of nanosensors has emerged as a promising solution, leveraging the unique properties of nanomaterials to facilitate rapid, reliable, and sensitive detection of aspirin. From a neuropharmaceutical perspective, the role of aspirin extends beyond its anti-inflammatory properties, as it also influences neurovascular health and may modulate neuroinflammatory processes associated with stroke. This review synthesizes current research findings, explores the mechanisms underlying nanosensor functionality, and addresses the challenges and future directions in the field of aspirin detection. By providing a comprehensive overview of cutting-edge research on aspirin nanosensors, this study underscores the importance of advancing detection technologies to improve patient outcomes, particularly in stroke prevention and management, and ensure effective therapeutic monitoring, while emphasizing the need for interdisciplinary approaches that integrate neuropharmaceutical insights to enhance the understanding of aspirin's multifaceted role in neuroprotection and its implications for stroke therapy.