Object: Utilizing whole-brain functional magnetic resonance imaging(fMRI) to investigate abnormal spontaneous brain activity in the resting state of patients with trigeminal neuralgia (TN) and explore their relationship with pain symptoms and negative emotions.
Methods: This study included 46 patients with TN diagnosed at our hospital from December 2022 to June 2023 and 35 healthy controls (HCs). All patients with TN completed questionnaires related to pain and emotions. The data analysis used the DPABI toolkit based on MATLAB platform and compared amplitude of low frequency fluctuation (ALFF) in brain between TN and HC groups. To delve deeper, we will utilize Pearson correlation analysis to explore the intricate relationships between pain symptoms, negative emotions, and brain functional abnormalities in patients of TN.
Result: Compared with HCs, patients of TN exhibited significantly reduced ALFF in the left superior frontal gyrus (SFG), bilateral middle frontal gyrus (MFG), bilateral inferior frontal gyrus (IFG), right precentral gyrus (PrG), right superior temporal gyrus (STG), bilateral middle temporal gyrus (MTG) , left inferior temporal gyrus (ITG), right cingulate gyrus (CG) (p<0.05). In correlation analysis, ALFF in the left SFG and right CG were negatively correlated with pain symptoms and negative emotions in patients of TN.
Conclusion: Patients of TN show functional abnormalities in several key brain regions that are involved in pain perception and emotional regulation. These abnormalities primarily manifest as a reduction in spontaneous neural activity. The ALFF in the left SFG and right CG is negatively correlated with the severity of pain and negative emotions, indicating that the more severe the pain and negative emotions in patients of TN, the more obvious the decrease in neural activity in specific brain regions. This suggests that the left SFG and right CG may be characteristic brain regions in the pathophysiological mechanism of TN.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.wneu.2025.123875 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Computerized adaptive resting with the I-HaND scale for monitoring patients with upper limb nerve pathology.
J Hand Surg Eur Vol
March 2025
1. Authorship: The authors are Mary Rose Harvey, Conrad Harrison and the Working group for computerised adaptive testing of the I-HaND. Underneath the main authors, the working group members should be listed as: Ryckie G Wade, Jeremy Rodrigues, Christina Jerosch-Herold, Caroline Miller, Christopher McGhee, Grainne Bourke, Chiraag Karia, Alna Dony, Dominic Power, Mark Ashwood.
The Impact of Hand Nerve Disorders scale is a patient-reported outcome measure for upper limb nerve pathology. We aimed to assess its structural validity using item response theory and to develop computerized adaptive testing algorithms. We conducted a series of psychometric studies to assess constructs measured, applied an item response theory model to the data, then developed computerized adaptive testing algorithms.
View Article and Find Full Text PDFEfficacy of a Supervised Exercise Program on Pain, Physical Function, and Quality of Life in Patients With Breast Cancer: Protocol for a Randomized Clinical Trial.
JMIR Res Protoc
March 2025
Paseo de los Encomendadores, Faculty of Health Sciences, University of Burgos, Burgos, Spain.
Background: Breast cancer is the second most common cancer in women worldwide. Treatments for this disease often result in side effects such as pain, fatigue, loss of muscle mass, and reduced quality of life. Physical exercise has been shown to effectively mitigate these side effects and improve the quality of life in patients with breast cancer.
View Article and Find Full Text PDFPrevalence and pattern of adverse events following COVID-19 vaccination among adult population in Sokoto metropolis, northwest, Nigeria.
PLoS One
March 2025
Department of Pharmacology and Therapeutics, Usmanu Danfodiyo University, Sokoto, Nigeria.
Background: COVID-19 still poses a major public health challenge worldwide and vaccination remains one of the major interventions to control the disease. Different types of vaccines approved by the World Health Organization (WHO) are currently in use across the world to protect against the disease. This study assessed the prevalence and pattern of adverse events following immunization (AEFI) after receiving COVID-19 vaccine (the Oxford-AstraZeneca vaccine) among the adult population in Sokoto metropolis, North-west, Nigeria.
View Article and Find Full Text PDFPlatelet-rich plasma (PRP) injections as a second-line treatment in patients with tendinopathy-related chronic pain and failure of conservative treatment: a systematic review and meta-analysis.
Pain Med
March 2025
Department of Anesthesiology and Pain Medicine, Université de Montréal, 2900 Boul. Edouard-Montpetit, Montréal, Québec, H3T 1J4, Canada.
Design: Platelet-rich plasma (PRP) is a popular treatment option in managing chronic tendinopathies, although the literature is inconsistent, mainly because of significant heterogeneity in patient populations. Patients who failed conservative management may respond differently than those who have not undergone first-line treatment. This systematic review and meta-analysis aimed to evaluate the efficacy of PRP injections in reducing pain and improving function in patients with chronic tendinopathy who failed conservative treatment.
View Article and Find Full Text PDFIsolated Fibula Fracture With Development of Acute Compartment Syndrome.
J Am Acad Orthop Surg Glob Res Rev
March 2025
From the Department of Orthopaedic Surgery, Boston Medical Center Pl, Boston, MA.
Compartment syndrome is an orthopaedic emergency with moderate-to-severe sequela (pain, muscle contracture, nerve damage, infection, rhabdomyolysis, renal failure, etc.) if inadequately treated and can be difficult to diagnose in a timely fashion. Further complicating timely diagnosis are atypical presentations resulting in compartment syndrome.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!