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Emerging PET radiotracers for vascular imaging.
Rheumatology (Oxford)
March 2025
Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
Imaging plays an important role in the clinical management of patients with large-vessel vasculitis (LVV), both to confirm the diagnosis at the time of initial presentation and to identify disease relapses in individuals with established disease. The big advantage of PET imaging over other non-invasive imaging modalities is the ability to employ targeted radionuclide probes to localize and track cellular pathways, providing in vivo assessments of disease activity. While 18F-fluorodeoxyglucose (FDG) has good diagnostic accuracy for LVV, this tracer is taken up by all glucose metabolizing cells in the vessel wall and so non-specific arterial uptake that is often unrelated to inflammatory disease activity can occur in patients despite a good clinical response to treatment.
View Article and Find Full Text PDFThe diagnostic yield of non-invasive testing features in cardiac amyloidosis.
Nucl Med Rev Cent East Eur
March 2025
Clinical Department of Nuclear Medicine and Radiation Protection, Clinical Hospital Centre Zagreb, Zagreb, Croatia.
Background: Cardiac amyloidosis (CA) is a progressive disease in which amyloid fibrils infiltrate the heart muscle. This study aimed to identify features from cardiac biomarkers, electrocardiography (ECG), and echocardiography that may distinguish between transthyretin amyloidosis (ATTR) scintigraphy-positive and negative patients.
Material And Methods: Seventy-eight consecutive patients, median age 69 years (range 34-81), with suspected CA, negative serum free light chains, and negative serum and urine protein electrophoresis with immunofixation, referred to cardiac scintigraphy between 2021 and 2024, were retrospectively enrolled.
Cardiac radionuclide imaging should play a more important role in China.
J Nucl Cardiol
March 2025
Department of Nuclear Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China. Electronic address:
Imaging small dynamic lesions using positron emission tomography and computed tomography: an F-sodium fluoride valvular phantom study.
Eur Heart J Imaging Methods Pract
January 2025
Departments of Medicine (Division of Artificial Intelligence in Medicine) and Biomedical Sciences, Cedars-Sinai Medical Center, 6500 Wilshire Blvd, Los Angeles, CA 90048, USA.
Aims: F-sodium fluoride (F-NaF) positron emission tomography (PET) detects active microcalcification and predicts adverse outcomes including bioprosthetic valve deterioration. However, measuring small areas of F-NaF uptake within moving structures remains challenging, requiring further optimization. We developed a representative cardiac phantom to optimize F-NaF imaging of bioprosthetic valves.
View Article and Find Full Text PDFAutomated Radiolabeling and Evaluation of [F]FPMBBG: A Novel Cardiac Neuronal PET Imaging Agent.
J Labelled Comp Radiopharm
March 2025
Department of Nuclear Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
This study reports the automated radiosynthesis and evaluation of [F]FPMBBG, a radiopharmaceutical designed to target the norepinephrine transporter (NET). A newly developed fully protected benzylguanidine precursor, which prevents interference from non-protected benzylguanidine part during the nucleophilic process, has enabled a one-pot two-step fully automated cassette-based synthesis of [F]FPMBBG. This advancement enhances the feasibility of the synthesis, ensures reproducibility, and allows for the production of substantial quantities of the radiotracer, paving the way for future clinical applications.
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