Fused heterocyclic imidazonaphthyridine compounds stand at the forefront of global research, captivating remarkable interest in medicinal and synthetic organic chemistry. These compounds possess a range of potent biological and pharmacological properties, rendering them invaluable for medical and therapeutic research, particularly in drug design and discovery. Despite their significance, no dedicated review has focused on fused heterocyclic imidazonaphthyridine derivatives. This comprehensive review aims to consolidate and explore the cutting-edge synthesis approaches tailored specifically for these unique imidazonaphthyridine derivatives. It highlights their current applications in various biological realms and provides insights into potential future trajectories. By steering forthcoming research endeavours towards innovative design and synthesis of novel imidazonaphthyridines, this review seeks to diversify these compounds, paving the way for biological applications that have yet to be fully realized. Overall, as a burgeoning area of research, this review underscores the potential of imidazonaphthyridines as promising candidates for biomedical applications, offering a snapshot of current research and suggesting future avenues for investigation.
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A comprehensive review of fused imidazonaphthyridine derivatives: Synthetic approaches and biological applications.
Bioorg Med Chem
February 2025
School of Science, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia. Electronic address:
Fused heterocyclic imidazonaphthyridine compounds stand at the forefront of global research, captivating remarkable interest in medicinal and synthetic organic chemistry. These compounds possess a range of potent biological and pharmacological properties, rendering them invaluable for medical and therapeutic research, particularly in drug design and discovery. Despite their significance, no dedicated review has focused on fused heterocyclic imidazonaphthyridine derivatives.
View Article and Find Full Text PDFDiscovery and evaluation of aza-fused tricyclic derivatives for detection of Tau pathology in Alzheimer's disease.
Eur J Med Chem
January 2023
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China; Center for Advanced Materials Research, Beijing Normal University, Zhuhai, 519087, China. Electronic address:
For various neurodegenerative diseases, including Alzheimer's disease (AD), the abnormal aggregation of Tau is not only the predominant contributing factor but also a major biomarker for disease diagnosis. In this study, a series of aza-fused tricyclic derivatives were designed and synthesized. By changing the position and number of nitrogen atoms on the fused tricyclic core, the imidazonaphthyridine scaffold was screened and reported for the first time which could potentially detect Tau aggregates.
View Article and Find Full Text PDFImidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity.
Eur J Med Chem
June 2012
U990 INSERM, rue Montalembert, BP 184, 63000 Clermont-Ferrand, France.
We recently discovered that five- and pseudo-five-fused-ring derivatives in an imidazonaphthyridine series were promising hit compounds for the development of new DNA-intercalators. In this study, novel (dihydro)imidazo[1,6] and [1,7]naphthyridi(no)nes were prepared including pseudo-pentacycles. All the compounds synthesized were screened against four tumor cell lines.
View Article and Find Full Text PDFEffect of solvents on the photophysical properties of substituted imidazonaphthyridine derivatives.
Spectrochim Acta A Mol Biomol Spectrosc
April 2000
Department of Physics, Anna University, Chennai, India.
The absorption and fluorescence characteristics of three substituted imidazonaphthyridine derivatives are studied in a series of organic solvents. The variation of Stokes shift with the polarity parameter of the solvent is studied and the excited state dipole moment of these derivatives is higher than the ground state dipole moment. The fluorescence lifetime profile shows single exponential decay in all the solvents.
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