Background: Osseointegrated prostheses (OIP) use is increasing for above-knee amputees who have difficulties with sockets. This study aims to simulate the bone-implant interface under loading using a 3D finite element (FE) model and quantify force distribution to produce hypotheses on bone remodelling and implant failure, informing implant and surgical design, and rehabilitation protocols.
Methods: Ten customised 3D femur FE models (5 female, 5 male) were generated from CT scans and bone-implant assemblies created. The bone was subdivided into seven Gruen Zones and four proximal femur regions. Boundary conditions were taken from the literature.
Results: The highest stresses were found in the implant (Max: 113.9 MPa), whilst highest strains were seen in the bone (Max: 4.89 %). Stress and strain were unevenly distributed, with distal regions experiencing stress shielding effects and areas around the implant tip experiencing significantly higher stresses and strains (p < .001). Maximum stresses were higher in female bones (p < .01), whilst shorter residuum lengths saw significantly lower stresses (p < .05).
Conclusion: Sex, size and limb length are all important factors and these need to be accounted for when designing and implanting OIPs.
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http://dx.doi.org/10.1016/j.medengphy.2025.104304 | DOI Listing |
OTA Int
March 2025
Atrium Health-Carolinas Medical Center, Atrium Health Musculoskeletal Institute, Charlotte, NC.
Purpose: Osseointegration-associated infections are a critical barrier to widespread implementation of osseointegrated (OI) prosthetics. To address this challenge, a preclinical animal model must exist of the human model to test potential interventions. In this article, we describe a novel rabbit model of OI implant-related infection that can act as a platform for rapid translation and development of therapeutic approaches to combat these uniquely challenging infections.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2025
National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, Sichuan, China.
Structural defects and biological inertness significantly impair the integration of titanium alloy implants and bone tissues. In spinal internal fixation, the issue of pedicle screw loosening or fracture caused by poor integration urgently needs solving. In this study, we utilized 3D printing technology to custom fabricate a structurally optimized porous pedicle screw with the aim of enhancing bone regeneration and integration at the defect site, thereby enhancing the biological fixation of the implant .
View Article and Find Full Text PDFMed Eng Phys
March 2025
Department of Bioengineering, Sir Michael Uren Hub, Imperial College London, White City, London W12 0BZ, UK.
Background: Osseointegrated prostheses (OIP) use is increasing for above-knee amputees who have difficulties with sockets. This study aims to simulate the bone-implant interface under loading using a 3D finite element (FE) model and quantify force distribution to produce hypotheses on bone remodelling and implant failure, informing implant and surgical design, and rehabilitation protocols.
Methods: Ten customised 3D femur FE models (5 female, 5 male) were generated from CT scans and bone-implant assemblies created.
Med Eng Phys
March 2025
INAIL Centro Protesi, via Rabuina 14, Vigorso di Budrio, 40054, Bologna, Italy. Electronic address:
Thumb amputations strongly affect hand functionality in daily activities. The currently available solutions, such as microsurgical treatments and external vacuum prostheses present disadvantages, which can be successfully addressed through the osseointegration technique. However, despite its widespread use in oral applications, only a few osseointegrated solutions for the treatment of hand-finger amputations are available.
View Article and Find Full Text PDFJ Assoc Res Otolaryngol
March 2025
Department of Otolaryngology, Head and Neck Surgery and Eaton Peabody Laboratories, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA.
Purpose: Cochlear implants (CI) are a highly successful neural prosthesis that can restore hearing in individuals with sensorineural hearing loss. However, the extent of hearing restoration varies widely. Two major factors likely contribute to poor performance: (1) the distances between electrodes and surviving spiral ganglion neurons and (2) the density of those neurons.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!