Introduction: Chronic venous insufficiency (CVI) is a complex condition characterized by venous hypertension that can cause pain, swelling, edema, skin changes, or ulcerations of the leg, involving either the deep or superficial venous system. Venous ulcerations result from elevated ambulatory venous pressure or venous hypertension, leading to limb edema. The mainstay of treatment for this edema has been and continues to be compression therapy. Despite optimal medical therapy with external compression, venous ulcers of the lower extremities can be a chronic, long-term problem with recurrence rates as high as 70 %.
Case Report: Herein, we describe a case of utilizing the best medical and surgical therapies including advanced wound care products to treat CVI and close chronic venous ulceration. A 66-year-old African American man with a history of heart failure and preserved ejection fraction, hypertension, hepatitis C, and CVI with recurrent bilateral venous ulcerations presented to the vascular surgery clinic for evaluation. Imaging was suggestive of normal arterial perfusion, and a venous reflux study, which was positive for diffuse venous reflux in the right leg along with an area of the greater saphenous vein in the calf with an arterial waveform concerning for arterial-venous fistula. He underwent sclerotherapy to the perforator vein, which was acting as an AVF feeding the ulceration. Conservative treatment with Unna boot and compression, the wound decreased in size and serial debridement with advanced wound care products were used to made to aid in the closure of this chronic wound.
Conclusion: Chronic venous insufficiency can lead to venous leg ulcerations, accounting for 80 % of all leg ulcerations. Treatment of the underlying CVI with surgical intervention and conservative compression therapy may not be enough to close a chronic venous ulcer alone. The SVS guidelines on managing venous ulcerations include comprehensive care, including compression therapy, local wound debridement, control of bioburden, wound moisture balance, and the possible use of advanced wound care products for chronic wounds.
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http://dx.doi.org/10.1016/j.jvn.2024.11.005 | DOI Listing |
Indian J Otolaryngol Head Neck Surg
February 2025
Department of ENT and Head and Neck Surgery, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
The present study aimed to assess and compare the effect of smoking on ultrastructure morphology of nasal mucosa between smokers and nonsmokers. The study included 50 subjects aged 25-62 years who were planned for rhinological surgical procedures. Subjects were divided into 3 groups- group 1 (nonsmoker), group 2 (smokers taking 1 pack/day or less), group 3 (smokers taking 2 pack/day or more).
View Article and Find Full Text PDFSci Rep
March 2025
Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Pogodinskaya str., 1, bld. 1, Moscow, 119435, Russian Federation.
Gut dysbiosis plays an important role in cirrhosis, but the mechanism of its development was not established. The aim of the study was to test the hypothesis that portal hypertension can be the main factor in the development of gut dysbiosis in cirrhosis. This cross-sectional study included 25 patients with chronic non-cirrhotic portal hypertension due to extrahepatic portal vein obstruction after portal vein thrombosis (PVT) (NCPVT group), 29 cirrhotic patients without PVT (CirNoPVT), 15 cirrhotic patients with chronic PVT (CPVT), and 22 healthy controls.
View Article and Find Full Text PDFScand Cardiovasc J
March 2025
Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden.
The adipocyte-derived hormone leptin has been associated with the pathogenesis of cardiovascular disease. The mechanisms underlying this association are unclear but may relate to effects on the vascular endothelium. Our aim was to explore the effects of leptin on endothelial vasomotor and fibrinolytic function in healthy volunteers and patients with coronary artery disease.
View Article and Find Full Text PDFJ Asthma
March 2025
Department of Clinical Biochemistry, Zealand University Hospital, Køge, Denmark.
Background: Long-term consequences after a pulmonary embolism include lung function deficits, dyspnea, and chronic thromboembolic pulmonary hypertension. Recent studies suggest patients who experience pulmonary embolism may also be at increased risk of asthma.
Methods: We tested the hypothesis that individuals with pulmonary embolism or deep vein thrombosis (venous thromboembolism) have lower lung function, or higher risks of dyspnea and asthma using data from 21,205 random adults from the Danish General Suburban Population Study.
Ann Hepatol
March 2025
Department of General, Visceral and Transplant Surgery, University Hospital Münster, Münster, Germany. Electronic address:
Introduction And Objectives: Liver resection is the standard treatment for resectable liver tumors and metastases. However, mortality and morbidity remain significant concerns, particularly for patients with chronically elevated central venous pressure (CVP), which increases perioperative complication risks. The optimal parenchymal transection technique for these patients remains unclear, necessitating further research.
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