Problem: The Vascular Surgery department at a large academic institution lacked a formalized approach to manage complex pain experienced by patients undergoing major limb amputation (MLA). Consequently, MLA patients averaged 2,352.2 total morphine milliequivalent (MME) and had prolonged hospitalizations averaging 21 days.
Purpose: This quality improvement (QI) project is to create a formalized clinical approach for the provider to manage the MLA patient's pain effectively. This approach ensures the application of evidence-based regional anesthesia (RA) for all eligible MLA patients.
Methods: The 22 providers managing MLA patients assessed a numeric pain score (NPS) at the time of MLA consent. Patients reporting an NPS of four or higher were triaged into the RA section of this process where the provider requested RA application by the pain team. To ensure process completion, these clinicians completed an embedded MLA checklist in the daily progress note. Utilizing a QR code, the providers submitted identified barriers for implementation via a survey. The project lead performed chart audits assessing total MME, NPS, and length of stay (LOS).
Results: Vascular surgeons performed 11 MLAs, with 73 % completing the provider survey and 64 % compliance with the checklist. Of the MLA patients, 64 % reported NPS of four or higher, 57 % of which successfully received RA. The average NPS scores on post-operative day one improved from an average of 4.7 (pre-operative) to 3.2 on post-operative day one. However, the average NPS elevated to a score of five by discharge. These 11 MLA patients averaged a 28.4-day LOS and experienced a significant reduction (approximately 65 %) in total MME from pre-implementation requiring an average of 842.5 MME for their hospitalization.
Conclusions: While the new approach did not show improvement in LOS or NPS, there was a substantial reduction in total MME required by these patients. This formalized framework aids the effective management of the MLA patient's pain. For sustainability, improved education and sedation training of the advanced practice providers will allow for bedside RA application. There is a marked need to develop a formalized transition from RA to an oral pain regimen prior to discharge to provide adequate long-term coverage.
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http://dx.doi.org/10.1016/j.jvn.2024.11.003 | DOI Listing |
Sci Rep
March 2025
Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, Jiangsu Province, 210006, China.
Unlabelled: The edge effect (EE) of isolated restenosis at one or both ends of a stent is not reduced by drug-eluting stent (DES). The purpose of the study was to investigate the long-term outcome of 1-year subclinical DES-EE (sDES-EE), which was defined as any reduction in the minimal lumen area (MLA) at stent edge without any evidence of clinical ischemia. A total of 252 patients were enrolled from one of our previous randomized controlled studies, who were detected by optical coherence tomography (OCT) immediately after DES implantation and 1 year later.
View Article and Find Full Text PDFInfect Immun
March 2025
Institute of Molecular Biology, University Hospital Essen, University of Duisburg-Essen, Duisburg, North Rhine-Westphalia, Germany.
Respiratory infections with multiresistant are a major clinical problem, affecting mainly patients with pre-existing lung diseases such as cystic fibrosis (CF) or chronic obstructive pulmonary disease but also immunocompromised or elderly patients. We have previously shown that sphingosine, which is abundantly present on epithelial cells of the respiratory tract in healthy humans and wild-type mice, but almost undetectable on the surface of epithelial cells of the respiratory tract from CF patients and CF mice, efficiently kills many bacterial species and . Here, we show that sphingosine very rapidly induces marked changes in the membrane of with a rolling of the membrane followed by destruction of the bacteria.
View Article and Find Full Text PDFArch Rheumatol
December 2024
Department of Physical Medicine and Rehabilitation, Gazi University Faculty of Medicine, Ankara, Türkiye.
Objectives: This study aimed to investigate the association of medial longitudinal arch (MLA) height and stiffness with lower extremity alignment, pain, and disease severity in patients with knee osteoarthritis (OA).
Patients And Methods: This cross-sectional study included 90 patients (75 females, 15 males; mean age: 63.6±9.
J Vasc Nurs
March 2025
University of Maryland Medical Center, 22 South Greene Street Baltimore, MD, USA. Electronic address:
Problem: The Vascular Surgery department at a large academic institution lacked a formalized approach to manage complex pain experienced by patients undergoing major limb amputation (MLA). Consequently, MLA patients averaged 2,352.2 total morphine milliequivalent (MME) and had prolonged hospitalizations averaging 21 days.
View Article and Find Full Text PDFNat Med
March 2025
Center for Weight and Eating Disorders, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Current guidelines recommend behavioral treatment (BT) as the first intervention for patients with obesity. However, a substantial minority (35-50%) do not achieve a clinically meaningful loss of ≥5%. Anti-obesity medications (AOMs) are recommended when target weight loss is not achieved; however, their efficacy among BT nonresponders has not been established.
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