The advent of bacterial resistance has led to a notable challenge in effectively treating bacterial infections. This highlights the urgent need for the development of novel and effective drugs to combat bacterial infections. Medicinal plants, with their rich and diverse natural compounds, represent a valuable source for the discovery of novel antibacterial agents. Many of these natural compounds exhibit strong antibacterial functions, offering a promising direction for the development of antibacterial drugs. Furthermore, the application of nanotechnology in the development of antibacterial natural products has become a topic of considerable interest due to the advantages it offers, including the potential to enhance drug solubility. The efficacy of natural antibacterial agents is significantly enhanced through nanotechnology. This review offers a comprehensive overview of recent advances in the delivery of natural antibacterial compounds using a range of nanoformulation strategies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2025.125437 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Poly(vinyl alcohol)/Polycaprolactone Nanofiber Enriched with Lichenysin against Multidrug-Resistance Bacterial Infection in Wound Healing: In Vitro Studies and In Vivo Evaluation in Wistar Rats.
ACS Appl Bio Mater
March 2025
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India.
Multidrug resistance (MDR) infectious wounds are a major concern due to drug resistance, leading to increased patient morbidity. Lichenysin (LCN), a lipopeptide and biosurfactant obtained from certain strains of , has demonstrated an excellent antimicrobial property. The present study focuses on the fabrication and comprehensive evaluation of LCN-incorporated poly(vinyl alcohol) (PVA)/polycaprolactone (PCL)-based nanofiber scaffolds using an electrospinning technique as a potential wound healing biomaterial for the treatment of MDR infectious wounds in diabetic rats.
View Article and Find Full Text PDFInducible regulating homologous recombination enables precise genome editing in Pichia pastoris without perturbing cellular fitness.
Trends Biotechnol
March 2025
Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, PR China; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, PR China; Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, PR China. Electronic address:
The methylotrophic yeast Pichia pastoris (also known as Komagataella pastoris) is an ideal host for producing proteins and natural products. Enhancing homologous recombination (HR) is helpful for improving the precision of genome editing, but results in stress to cellular fitness and is harmful for industrial applications. To overcome these challenges, we developed a tetracycline repressor protein (TetR)/tetO2 inducible system to dynamically regulate the HR-related gene RAD52 in P.
View Article and Find Full Text PDFCorrigendum to "Antioxidant, antitumoral, antimetastatic effect and inhibition of collagenase enzyme activity of Eleutherine bulbosa (Dayak onion) extract: In vitro, in vivo and in silico approaches" [J. Ethnopharmacol. 318 (2024) 117005].
J Ethnopharmacol
March 2025
Fundação Educacional do Município de Assis (FEMA), Assis, São Paulo, Brazil.
Lewis-Base-Catalyzed Asymmetric Allylation of Isatins with Allyltrichlorosilane.
Org Lett
March 2025
Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany.
Herein we report the enantioselective synthesis of 3-allyl-3-hydroxyoxindoles, a core scaffold in a wide range of bioactive molecules, using a Lewis-base catalyst and readily abundant and inexpensive allyltrichlorosilane. This transition-metal-free protocol employs relatively low catalyst loadings of a privileged bispyrrolidine-type scaffold to achieve high yields and enantioselectivities (up to 98% yield and 98:2 er). The total syntheses of the natural products (-)-flustraminol B and (-)-chimonamidine were also successfully carried out using our newly developed method as a key step, highlighting the potential of this method for the efficient and precise synthesis of complex natural products.
View Article and Find Full Text PDFApplication of chemical pattern recognition and similarity evaluation in electrochemical and HPLC-DAD fingerprints for quality consistency study of herbal medicines.
Anal Chim Acta
May 2025
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China. Electronic address:
Background: Herbal medicines and their preparations play a significant role in healthcare systems, yet concerns remain about their quality consistency. Chemical fingerprinting and multi-component quantitative analysis are the commonly used analytical methods and are widely applied in the quality analysis of herbal medicines. The study uses Gegen Qinlian tablets (GQTs) as a case to propose a comprehensive quality consistency evaluation system.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!