Background: Temporal Interference Stimulation (TIS) is a non-invasive approach to deep brain stimulation. However, most research has focused on the intensity of modulation, with limited attention given to the directional properties of the induced electric fields, despite their potential importance for precise stimulation.
New Methods: A novel analytical framework was developed to analyze TIS-induced electric field directions using individual imaging data. For each voxel, the direction corresponding to the maximal modulation depth was calculated. The consistency of these directions within regions of interest (ROIs) and their alignment with the ROI principal axes, derived from principal component analysis (PCA), were assessed.
Results: Simulations revealed complex spatial and temporal trajectories of the electric field at the voxel level. In the left putamen, the maximal modulation depth reached 0.241 ± 0.041 V/m, whereas in the target region, the left hippocampus, it was lower (0.15 ± 0.032 V/m). Notably, in the left hippocampus, the directions of maximal modulation depth were predominantly perpendicular to its longitudinal axis (84.547 ± 8.776°), reflecting structural specificity across its anterior, middle, and posterior regions.
Comparison With Existing Methods: Unlike previous approaches, this study integrates directional analysis into TIS modeling, providing a foundation for precise stimulation by exploring structural alignment.
Conclusion: Our analysis revealed that the orientations of maximal modulation depth in the left hippocampus were perpendicular to its longitudinal axis under the current electrode configuration, but they shifted to parallel alignment when the electrode pairs were swapped. This directional specificity offers insights for optimizing TIS by aligning with structural features, presenting a potential strategy to enhance stimulation precision and broaden its clinical and research applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jneumeth.2025.110416 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
EZH2 coordinates memory B-cell programming and recall responses.
J Immunol
March 2025
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.
Antigen-experienced memory B-cells (MBC) are endowed with enhanced functional properties compared to naïve B cells and play an important role in the humoral response. However, the epigenetic enzymes and programs that govern their rapid differentiation are incompletely understood. Here, the role of the histone H3 lysine 27 methyltransferase EZH2 in the formation of MBC in response to an influenza infection was determined in Mus musculus.
View Article and Find Full Text PDFCytochrome c and Ouabain Binding Site of Na,K-ATPase.
Cell Biochem Biophys
March 2025
Georgian National University, 9 Tsinandali Str., Tbilisi, Georgia.
Na,K-ATPase is an electrogenic pump found in cell plasma membranes that acts as the basic unit of animal life. This enzyme is highly susceptible to cardiotonic steroid (CTS) inhibition. The role of Na,K-ATPase in signaling has introduced a novel viewpoint regarding the enzyme's function, as the ouabain-binding site is involved in several physiological processes.
View Article and Find Full Text PDFBackground: People with cystic fibrosis (pwCF) often have multifactorial peripheral muscle abnormalities attributed to, for example, malnutrition, steroid use, altered redox balance and, potentially, CF-specific intrinsic alterations. Malnutrition in CF now includes an increasing prevalence of overweight and obesity, particularly in those receiving CF transmembrane conductance regulator (CFTR) modulator therapy (CFTRm). We aimed to characterise peripheral muscle function and body composition in pwCF on Elexacaftor/Tezacaftor/Ivacaftor (ETI) CFTRm, compared to healthy controls.
View Article and Find Full Text PDFGlycyrrhizin enhances the antitumor activity of cisplatin in non‑small cell lung cancer cells by influencing DNA damage and apoptosis.
Oncol Lett
April 2025
Department of General Practice, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China.
The objective of the present study was to elucidate the mechanism by which glycyrrhizin enhances the antitumor activity of cisplatin in non-small cell lung cancer. Initially, A549 cells were treated with different concentrations of glycyrrhizin (0.25-8 mM) or cisplatin (10-160 µM) for 48 h to investigate the effect of glycyrrhizin combined with cisplatin on A549 cells .
View Article and Find Full Text PDFAdvancing personalized digital therapeutics: integrating music therapy, brainwave entrainment methods, and AI-driven biofeedback.
Front Digit Health
February 2025
Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Mental health disorders and cognitive decline are pressing global concerns, increasing the demand for non-pharmacological interventions targeting emotional dysregulation, memory deficits, and neural dysfunction. This review systematically examines three promising methodologies-music therapy, brainwave entrainment (binaural beats, isochronic tones, multisensory stimulation), and their integration into a unified therapeutic paradigm. Emerging evidence indicates that music therapy modulates affect, reduces stress, and enhances cognition by engaging limbic, prefrontal, and reward circuits.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!