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Market and Non-Market Productivity Losses Associated with Invasive Meningococcal Disease in the USA.
Pharmacoeconomics
March 2025
GSK, Wavre, Belgium.
Background And Objective: Invasive meningococcal disease (IMD) is an uncommon but serious disease associated with a risk of death and severe long-term sequelae, impacting both patients and their caregivers. Productivity losses due to IMD have not previously been comprehensively evaluated in the USA. This study evaluated both market and non-market productivity losses to better estimate the economic burden of IMD in the USA.
View Article and Find Full Text PDFRecent advancements in genistein nanocarrier systems for effective cancer management.
Med Oncol
March 2025
Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, 281406, India.
Cancer continues to be a significant global health concern, consistently ranking as one of the leading causes of mortality across diverse populations and socio-economic contexts. Genistein, a soy-derived isoflavonoid, has gained significant attention for its diverse health benefits, particularly its potent anticancer activity. Emerging pre-clinical and clinical evidences highlights its ability to modulate key cellular processes, including apoptosis, autophagy, angiogenesis, metastasis, immune responses and cell cycle regulation.
View Article and Find Full Text PDFThe biotechnological and economic potential of macroalgae in the Baltic Sea.
Planta
March 2025
Phycology Laboratory, Faculty of Oceanography and Geography, University of Gdańsk, Al. Marszałka Piłsudskiego 46, 81-378, Gdynia, Poland.
Baltic Sea macroalgae exhibit unique bioactive compounds and diverse applications, supporting sustainable industries in food, cosmetics, and medicine while promoting environmental restoration. Common in the Baltic Sea, macroalgae hold great biotechnological and commercial promise in various industries, such as food, cosmetics, and medicines. The present study investigates the various uses of the Baltic macroalgae, emphasizing their nutritional worth, which encompasses vital amino acids, vitamins, and minerals, as well as their suitability as natural gelling agents, food additives, and dietary supplements.
View Article and Find Full Text PDFE3 ubiquitin ligase MARCH5 positively regulates Japanese encephalitis virus infection by catalyzing the K27-linked polyubiquitination of viral E protein and inhibiting MAVS-mediated type I interferon production.
mBio
March 2025
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Membrane-associated RING-CH-type finger (MARCH) proteins, a class of E3 ubiquitin ligases, have been reported to be involved in the infection of multiple viruses and the regulation of type I interferon (IFN) production. However, the specific role and mechanisms by which MARCH proteins influence Japanese encephalitis virus (JEV) infection remain poorly understood. Here, we systematically investigate the functional relevance of MARCH proteins in JEV replication by examining the effects of siRNA-mediated knockdown of MARCHs on viral infection.
View Article and Find Full Text PDF"Rigorous and Systematic Qualitative Data Analysis in Biological Anthropology".
Am J Biol Anthropol
December 2024
Arizona State University, Tempe, Arizona, USA.
Biological anthropologists have long engaged in qualitative data analysis (QDA), though such work is not always foregrounded. In this article, we discuss the role of rigorous and systematic QDA in biological anthropology and consider how it can be understood and advanced. We first establish what kinds of qualitative data and analysis are used in biological anthropology.
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