Groundwater serves as an indispensable resource for freshwater, but its quality has experienced a notable decline over recent decades. Spatial prediction of groundwater quality (GWQ) can effectively assist managers in groundwater remediation, management, and risk control. Based on the traditional intrinsic groundwater vulnerability (IGV) model (DRASTIC) and three vegetation (V) indicators (NDVI, EVI, and kNDVI) and four human activity (H) indicators (land use, GDP, urbanization index, and nighttime light), we constructed four models for GWQ spatial prediction in the Jianghan Plain (JHP), namely DRASTI, DRASTIH, DRASTIV, and DRASTIVH, excluding the conductivity (C) indicator due to its uniformly low values. LightGBM algorithm, Tree-structured Parzen Estimator (TPE) optimization method, and SHapley Additive exPlanations (SHAP) analysis are used for model setting, calibration, and interpretation, respectively. The results show that nitrogen-related GWQ parameters have higher weights, and the model performs exceptionally well when considering all the indicators (accuracy = 0.840, precision = 0.824, recall = 0.832, F score = 0.828, AUROC = 0.914). Notably, the introduced indicators (NDVI, EVI, kNDVI, nighttime light, GDP, and urbanization index) rank as the top six in terms of importance, while traditional DRASTI and land use indicators show lower significance. Based on SHAP analysis, poor GWQ primarily occurs in areas with either extremely high or extremely low GDP and urbanization index values, and human activities are the primary cause of poor GWQ in JHP, potentially involving urbanization, industrial and agricultural activities, as well as fertilizer usage. Finally, the methodological framework proposed in this study is encouraged to be applied to diverse regions, such as plains, karst areas, mountainous regions, and coastal areas, to support effective future groundwater management.
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