Increased research on early psychosis treatment and clinical outcomes has prompted interest in greater understanding of the efficacy of coordinated specialty care (CSC) across the United States. CSC clinics have become the standard for early psychosis care and act as a venue through which learning health systems (LHS) can be established. A learning health system integrates research findings into clinical care to create a continuous feedback loop. The Laboratory for Early Psychosis (LEAP) Center's position as a part of a learning health system in Massachusetts serves to improve care across the state through ongoing research on the effectiveness of early psychosis interventions. The following report highlights the LEAP Center's foundation as an LHS, as well as the systems and relationships that contribute to the success of learning health systems. Recommendations and practical applications are explored for interested stakeholders to implement an LHS that best serves their populations.
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http://dx.doi.org/10.1016/j.schres.2025.02.016 | DOI Listing |
Psychol Med
March 2025
Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Background: Population-level preventive interventions are urgently needed and may be effective for psychosis due to social determinants. We tested three syndemic models along pathways from childhood adversity (CA) to psychotic spectrum disorder (PSD) and their implications for prevention.
Methods: Cross-sectional data from 7461 British men surveyed in 5 population subgroups.
Handb Clin Neurol
March 2025
Department of Psychology, Durham University, England, United Kingdom. Electronic address:
This chapter will critically review evidence across 40 years of research, covering both early and contemporary studies that have investigated sex/gender differences in hemispheric asymmetries, including both structural and functional asymmetries. We argue that small sex/gender differences in hemispheric asymmetry reliably exist, but there is significant overlap between the sexes and considerable within-sex variation. Furthermore, we argue that research to date is limited in its consideration of sex/gender-related factors, such as sex hormones and gender roles.
View Article and Find Full Text PDFActa Psychol (Amst)
March 2025
Tunis Al Manar University, Faculty of Medicine of Tunis, Tunis, Tunisia; The Tunisian Center of Early Intervention in Psychosis, Department of Psychiatry Ibn Omrane, Razi Hospital, Tunis, Tunisia.
Background: University students face numerous challenges, which may adversely influence their mental/physical well-being and academic performance. Satisfaction with life implicates the psychological, social, and educational functioning of students-justifying its use for clinical screening and monitoring of treatment outcomes.
Objective: Given the growing interest in the equivalence of this construct across cultures, this study assessed the structure and invariance of the Satisfaction with Life Scale (SWLS) and its three-item version (SWLS-3).
Elife
March 2025
Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, Prague, Czech Republic.
Longitudinal neuroimaging studies offer valuable insight into brain development, ageing, and disease progression over time. However, prevailing analytical approaches rooted in our understanding of population variation are primarily tailored for cross-sectional studies. To fully leverage the potential of longitudinal neuroimaging, we need methodologies that account for the complex interplay between population variation and individual dynamics.
View Article and Find Full Text PDFPsychol Med
March 2025
Orygen, Parkville, VC, Australia.
Background: To improve early intervention and personalise treatment for individuals early on the psychosis continuum, a greater understanding of symptom dynamics is required. We address this by identifying and evaluating the movement between empirically derived attenuated psychotic symptomatic substates-clusters of symptoms that occur within individuals over time.
Methods: Data came from a 90-day daily diary study evaluating attenuated psychotic and affective symptoms.
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