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Beyond pills and prescriptions: Exploring aging-related diseases with non-pharmacological strategies and molecular innovations.
Aging Dis
February 2025
International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia.
This paper provides a thorough examination of aging-related diseases, exploring into the intricate molecular mechanisms that underline their development and progression. It explores cutting-edge therapeutic interventions aimed at addressing these conditions, with a particular focus on non-pharmacological approaches such as personalized lifestyle modifications, cognitive enhancement strategies, and robust social engagement initiatives. Additionally, it highlights emerging modalities including gene therapy and precision medicine as promising avenues for mitigating the challenges associated with age-related ailments.
View Article and Find Full Text PDFUnraveling the impact of congenital deafness on individual brain organization.
Elife
March 2025
Department of Neuroscience, Georgetown University Medical Center, Washington DC, United States.
Research on brain plasticity, particularly in the context of deafness, consistently emphasizes the reorganization of the auditory cortex. But to what extent do all individuals with deafness show the same level of reorganization? To address this question, we examined the individual differences in functional connectivity (FC) from the deprived auditory cortex. Our findings demonstrate remarkable differentiation between individuals deriving from the absence of shared auditory experiences, resulting in heightened FC variability among deaf individuals, compared to more consistent FC in the hearing group.
View Article and Find Full Text PDFPhase Precession Relative to Turning Angle in Theta-Modulated Head Direction Cells.
Hippocampus
March 2025
UCL Institute of Cognitive Neuroscience, University College London, London, UK.
Grid and place cells typically fire at progressively earlier phases within each cycle of the theta rhythm as rodents run across their firing fields, a phenomenon known as theta phase precession. Here, we report theta phase precession relative to turning angle in theta-modulated head direction cells within the anteroventral thalamic nucleus (AVN). As rodents turn their heads, these cells fire at progressively earlier phases as head direction sweeps over their preferred tuning direction.
View Article and Find Full Text PDFCognitive performance is associated with return to work after ischemic stroke in young adults: The ODYSSEY study.
Eur Stroke J
March 2025
Department of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.
Introduction: Limited data exist on cognitive performance and return to work after ischemic stroke, especially in patients under 50 years. We investigated whether cognitive performance in the subacute phase after ischemic stroke in young adults was associated with unemployment and the inability to retain their jobs among those who returned to work.
Patients And Methods: We conducted a multicenter prospective cohort study between 2013 and 2021, enrolling patients aged 18-49 years with first-ever ischemic stroke.
Emotion Induction Modulates Neural Dynamics Related to the Originality of Ideational Creativity.
Hum Brain Mapp
March 2025
School of Business, Social and Decision Sciences, Constructor University, Bremen, Germany.
Emotions remarkably impact our creative minds; nevertheless, a comprehensive mapping of their underlying neural mechanisms remains elusive. Therefore, we examined the influence of emotion induction on ideational originality and its associated neural dynamics. Participants were randomly presented with three short videos with sad, neutral, and happy content.
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