In the first part of this work (Rodriguez et al. 2016), the selective focusing through identification and experimental acoustic signature extraction (SelF-EASE) method was presented, and its potential for accurate ultrasound focusing was assessed via numerical experiments. In the second part of this work, the inversion procedure and focusing signal extraction are improved in terms of reliability and computation time, and experimental results are presented. First, the improved signature extraction process is evaluated with two experimental aluminum samples. Second, the improved focusing process is experimentally performed on a target immersed in water behind an unknown aberration layer. Compared with the time-of-flight methods, the measured intensity fields greatly improve in terms of accuracy without any further knowledge of the medium.
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http://dx.doi.org/10.1016/j.ultras.2025.107605 | DOI Listing |
Lipids Health Dis
March 2025
Department of Human Neuroscience, Faculty of Medicine and Dentistry, Sapienza, University of Rome, Rome, Italy.
Introduction: This systematic review explores the hypothesis that various lipid categories and lipid metabolism-related genomic variations link to mental disorders, seeking potential clinically useful markers.
Methods: We searched PubMed, Scopus, and PsycInfo databases until October 12th, 2024, using terms related to lipidomics, lipid-related genomics, and different mental disorders, i.e.
J Exp Clin Cancer Res
March 2025
Advanced Pathology Laboratory, IFOM ETS, the AIRC Institute of Molecular Oncology, Via Adamelllo 16, Milan, 20239, Italy.
Background: The identification of molecular features characterizing metastatic disease is a critical area of oncology research, as metastatic foci often exhibit distinct biological behaviors compared to primary tumors. While the focus has largely been on the neoplastic cells themselves, the characterization of the associated stroma remains largely underexplored, with significant implications for understanding metastasis.
Main Body: By employing spatially resolved transcriptomics, we analyzed the transcriptional features of primary breast adenocarcinoma and its associated metastatic foci, on a representative set of microregions.
BMC Med Imaging
March 2025
Imaging Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Objectives: To evaluate the performance of CT-based intralesional combined with different perilesional radiomics models in predicting the microvascular density (MVD) of hepatic alveolar echinococcosis (HAE).
Methods: This study retrospectively analyzed preoperative CT data from 303 patients with HAE confirmed by surgical pathology (MVD positive, n = 182; MVD negative, n = 121). The patients were randomly divided into the training cohort (n = 242) and test cohort (n = 61) at a ratio of 8:2.
Discov Oncol
March 2025
Department of Emergency Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People's Republic of China.
Background: Recently, oxidative stress and inflammatory responses have been shown to directly impact tumor growth and the tumor microenvironment (TME). However, more research is necessary to fully understand the relationship between oxidative stress and inflammatory responses and colorectal cancer (CRC).
Methods: The FindCluster algorithm was used to extract CRC Single-cell RNA sequencing (scRNA-seq) data and identify tumor cell groupings.
Alveolar bone supports and anchors teeth. The parathyroid hormone-related protein (PTHrP) pathway plays a key role in alveolar bone biology. Salt inducible kinases (SIKs) are important downstream regulators of PTH/PTHrP signaling in the appendicular skeleton, where SIK inhibition increases bone formation and trabecular bone mass.
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