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Transformative Results in Giant Pyoderma Gangrenosum with Dexamethasone-cyclophosphamide Pulse.
Ann Afr Med
March 2025
Department of Dermatology, Dr. D. Y. Patil Medical College and Hospital, Pune, Maharashtra, India.
Pyoderma gangrenosum (PG) is a cutaneous ulcerative condition that can present in various forms, including ulcerative, bullous, pustular, vegetative, and peristomal. It often occurs and recurs in areas subjected to trauma due to the pathergy phenomenon, where irritation or injury triggers flare-ups. The condition typically begins as a painful erythematous lesion that rapidly progresses to a necrotic or blistering ulcer.
View Article and Find Full Text PDFPyoderma gangrenosum with extracutaneous involvement: a systematic review.
Clin Exp Dermatol
March 2025
Department of Dermatology, Oregon Health & Science University, Portland, OR, USA.
Gasdermin D-dependent neutrophil extracellular traps exacerbate cytokine storm contributing to pyoderma gangrenosum pathogenesis.
iScience
March 2025
Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Pyoderma gangrenosum (PG) is characterized by the agonizing necrotizing ulcers with non-infectious neutrophil infiltration. Neutrophil extracellular traps (NETs) represent one of the mechanisms of neutrophils activation, and gasdermin D (GSDMD) plays a regulatory role in NETs. In this study, we discovered that the serum levels of NETs were elevated in PG patients compared to healthy controls.
View Article and Find Full Text PDFUltra-High Frequency Ultrasound (UHFUS) Features of Pyoderma Gangrenosum, Venous Leg Ulcers, and Acute Ulcerative Lesions.
Int J Low Extrem Wounds
March 2025
Department of Dermatology, University of Pisa, Pisa, Italy.
Pyoderma gangrenosum (PG) is a neutrophilic dermatological disorder, marked by the dysregulation of both innate and adaptive immunity. Recently, non-invasive imaging techniques, including the use of Ultra-High Frequency Ultrasound (UHFUS), have been used to assess patients with PG. The primary objective of this study is to characterize the UHFUS differences among various cutaneous ulcerative diseases.
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