Two new cyclopentanoid monoterpenes, catalpovatins A-B (-), together with nine known compounds (-), were isolated from the fruits of G. Don. The structures of these compounds were elucidated based on their spectroscopic data. All isolated compounds were evaluated for cytotoxicity against six human tumor cell lines, hepatoprotective activity and anti-inflammatory activity.
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Two new cyclopentanoid monoterpenes from the fruits of .
J Asian Nat Prod Res
March 2025
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Two new cyclopentanoid monoterpenes, catalpovatins A-B (-), together with nine known compounds (-), were isolated from the fruits of G. Don. The structures of these compounds were elucidated based on their spectroscopic data.
View Article and Find Full Text PDFThree new cyclopentanoid monoterpenes from the roots of .
J Asian Nat Prod Res
January 2025
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Three new cyclopentanoid monoterpenes, neopiscrocins A-C (-), together with 14 known compounds (-), were isolated from the roots of . The structres of these compounds were elucidated on the basis of their spectroscopic data. All compounds were evaluated for cytotoxicity against six human tumor cell lines (PC9, PANC1, HCT-116, Hep-G2, BGC-823, and MCF-7), hepatoprotective activity and anti-inflammatory activity.
View Article and Find Full Text PDFTen cyclopentanoid monoterpenes from the whole plant of Rehmannia piasezkii maxim.
Fitoterapia
June 2024
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address:
Ten new cyclopentanoid monoterpenes (1-10) were isolated from the whole plant of Rehmannia piasezkii. The structures of these compounds were elucidated based on spectroscopic data analysis. In in-vitro assays, compounds 3, 7, and 9 exhibited weak hepatoprotective activities against APAP-induced HepG2 cell damage.
View Article and Find Full Text PDFGeniposide inhibits cell proliferation and migration in human oral squamous carcinoma cells via AMPK and JNK signaling pathways.
Exp Ther Med
December 2022
Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Institute of Agro-Bioengineering and College of Life Sciences, Guizhou University, Guiyang, Guizhou 550025, P.R. China.
Iridoids are a special class of cyclopentanoid monoterpenes, which exhibit a wide range of biological effects. The present study aimed to investigate the potential effects of three iridoids genipin, geniposide and geniposidic acid on three human oral squamous cell carcinoma (OSCC) cell lines HSC-2, SCC-9 and A253 in addition to studying the possible underlying mechanisms. Cell viability assay revealed that geniposide treatment significantly suppressed the proliferation of all three cancer cell lines.
View Article and Find Full Text PDFBiosynthesis of iridoid sex pheromones in aphids.
Proc Natl Acad Sci U S A
October 2022
Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany.
Iridoid monoterpenes, widely distributed in plants and insects, have many ecological functions. While the biosynthesis of iridoids has been extensively studied in plants, little is known about how insects synthesize these natural products. Here, we elucidated the biosynthesis of the iridoids -nepetalactol and -nepetalactone in the pea aphid (Harris), where they act as sex pheromones.
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