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Fueling defense: PPARα enhances macrophage inflammatory responses.
Cell Mol Immunol
March 2025
Department of Medical Biochemistry, Amsterdam institute for Immunology and Infectious Diseases, Immunology, Amsterdam Cardiovascular Sciences, Atherosclerosis, Amsterdam UMC, location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Comment on "Ovarian stimulation response and fertility outcomes in patients with breast cancer across different stages, grades, and hormone receptor status for fertility preservation".
J Formos Med Assoc
March 2025
Department of Gynaecology, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, 311200, Zhejiang, China. Electronic address:
SUMO style defense: How post-translational modification via SUMO conjugation promotes plant defense.
Dev Cell
March 2025
Max Perutz Labs, Department of Biochemistry and Cell Biology, University of Vienna, A1030 Vienna, Austria. Electronic address:
SUMOylation is a reversible post-translational modification that contributes to various biological processes in plants. In this issue of Developmental Cell, Zhang et al. show that covalent attachment of SUMO to PROPEP proteins promotes their proteolytic cleavage by metacaspase to release small signaling peptides (plant elictor peptides [PEPs]), triggering the release of the mature peptide in response to cell wall damage.
View Article and Find Full Text PDFEpidural analgesia during esophagectomy and esophageal cancer prognosis: A population-based nationwide study in Finland.
Acta Anaesthesiol Scand
April 2025
Surgery Research Unit, Oulu University Hospital and University of Oulu, Oulu, Finland.
Background: The use of epidural analgesia has been proposed to improve the prognosis of esophageal cancer by attenuating the stress response and being less immunosuppressive than opioids. This study aims to evaluate the association, if any, between non-epidural pain management compared to epidural analgesia during minimally invasive or open esophagectomy and esophageal cancer prognosis.
Materials And Methods: This was a population-based nationwide retrospective cohort study in Finland, using the Finnish National Esophago-Gastric Cancer Cohort (FINEGO).
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