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http://dx.doi.org/10.1186/s12916-025-03980-9 | DOI Listing |
Neurobiol Aging
March 2025
Neuroscience and Behavioural Diseases and Eye-ACP, SERI/SNEC, Centre for Vision Research, Duke-NUS Medical School, 8 College Road, 169857, Singapore; Save Sight Institute, University of Sydney, Sydney, NSW, Australia. Electronic address:
Increasing age and elevated intraocular pressure (IOP) are the two major risk factors for glaucoma, the most common cause of irreversible blindness worldwide. Accumulating evidence is pointing to metabolic failure predisposing to neuronal loss with advancing age and IOP injury. Many neurotransmitters are synthesized from endogenous metabolites and are essential for correct cell to cell signaling along the visual pathways.
View Article and Find Full Text PDFJ Steroid Biochem Mol Biol
March 2025
Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, L8S 4M1, Canada. Electronic address:
Vitamin D deficiency (VDD) is prevalent globally and in pediatric intensive care units, where it represents a modifiable risk factor that may impact patient recovery during hospitalization. Herein, we performed a retrospective analysis of serum samples from a phase-II randomized placebo-controlled trial involving a single large bolus of 10,000 IU/kg vitamin D3 ingested by critically ill children with VDD (25-OH-D < 50 nmol/L). Targeted and untargeted methods were used to comprehensively measure 6 vitamin D metabolites, 239 lipids, 68 polar metabolites, and 4 electrolytes using a multi-step data workflow for compound authentication.
View Article and Find Full Text PDFInt J Biol Macromol
March 2025
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, RP, China. Electronic address:
Hibernation poses significant physiological challenges to the animals, making it an excellent model for investigating the impacts of extreme environment changes on animal health. This study explored the gut microbiota and host metabolism in hibernating snakes using 16S rRNA gene sequencing and untargeted metabolomics. Ten king ratsnakes were divided into active and hibernating groups, and their gut microbial compositions and serum metabolomic profiles were analyzed.
View Article and Find Full Text PDFBMC Med
March 2025
Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China.
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