Background: To explore a novel semi-automatic quantitative method for detecting lid-wiper epitheliopathy (LWE) and analyze its impact on the distribution of corneal epithelial thickness (CET).
Methods: A total of 37 eyes from 37 adults were included in this study. The lid wipers were stained with lissamine green strips, and the stained areas were recorded using a digital slit-lamp biomicroscopy and analyzed using ImageJ software. Factors such as age, sex, and refraction were included as variables that influenced LWE. The CET was divided into 25 regions and recorded using spectral-domain optical coherence tomography.
Results: Methodological consistency and repeatability were verified through intra- and inter-operator intraclass correlation coefficients, with values of 0.889 and 0.922, respectively. After adjusting for age, sex, and spherical equivalent refraction, a negative correlation was observed between LWE and epithelial thickness. Specifically, negative correlations were observed in the nasal, subnasal, and inferior regions within the 2-5 mm range; subnasal and infratemporal regions within the 5-7 mm range; and the infratemporal region within the 7-9 mm range.
Conclusions: This study validated a novel method for assessing the severity of LWE by quantitatively analyzing the LWE area. Additionally, LWE is associated with thinning of the inferior corneal epithelium.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887165 | PMC |
| http://dx.doi.org/10.1186/s12886-025-03918-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The protective effect of curcumin on the diabetic uterus: Quantitative and qualitative evaluation.
Tissue Cell
March 2025
Department of Histology and Embryology, Ondokuz Mayıs University, Samsun, Turkey. Electronic address:
Background: The objective of this study was to examine the impact of diabetes on the rat uterus and to assess the potential therapeutic benefits of curcumin in a diabetic uterus.
Materials And Methods: A total of thirty-eight female Wistar albino rats were randomly assigned to seven experimental groups. The control group (Cont) was not subjected to any treatment.
Predictors of Dysplasia in Oral Submucous Fibrosis: A Retrospective Observational Study.
Cureus
February 2025
Department of Oral and Maxillofacial Pathology, Jawahar Medical Foundation's Annasaheb Chudaman Patil Memorial Dental College, Dhule, IND.
Introduction: Oral submucous fibrosis (OSMF) is a progressive, potentially malignant disorder often associated with areca nut and tobacco consumption. Dysplasia, a key predictor of malignant transformation, is poorly understood in terms of its association with clinical and histopathological factors. This study aimed to identify the clinical and histopathological predictors of dysplasia in OSMF to enhance diagnostic accuracy and risk stratification.
View Article and Find Full Text PDFThe influence of amniotic membrane proteins on corneal regeneration when delivered directly or using hydrogel platforms.
Front Med (Lausanne)
February 2025
Biogipuzkoa Health Research Institute, Donostia-San Sebastián, Spain.
Background/aims: Chemical burns to the eye cause extensive ocular surface damage, often resulting in permanent visual impairment. The amniotic membrane (AM), with its regenerative properties, has shown great potential in treating such injuries. Recent innovations, including hydrogel-based delivery systems, have been developed to improve drug retention and promote corneal healing.
View Article and Find Full Text PDFAcute ivermectin toxicity on skin and brain tissue of adult albino rats: Evaluation of the role of Flumazenil and Vitamin C as new treatment modalities.
Food Chem Toxicol
March 2025
Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, Kasr Alainy Street, Cairo 11562, Egypt. Electronic address:
Ivermectin, a natural antiviral drug, has been recommended for treating various diseases, including Coronavirus Disease 2019. This study aimed to evaluate the potential histopathological and biochemical changes in the skin and brain of adult albino rats treated with ivermectin, as well as the effectiveness of Vitamin C and flumazenil in their treatment. Thirty rats were divided into five treatment groups, each containing six rats.
View Article and Find Full Text PDFEpithelial Mapping Efficacy for Subclinical Keratoconus Identification.
Am J Ophthalmol
March 2025
Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA. Electronic address:
Purpose: To evaluate the utility of automated epithelial thickness metrics to identify subclinical keratoconus (SKC) through epithelial thickness pattern comparisons between normal controls, (SKC), and manifest keratoconus (KC).
Design: Retrospective cross-sectional study METHODS: There were 200 eyes from 200 patients evaluated, including: (1) 100 control eyes from 100 patients with bilaterally normal corneal topography/tomography and slit-lamp examination (controls); (2) 50 eyes from 50 patients with SKC; (3) 50 eyes from 50 patients with KC. Epithelial mapping was performed using anterior segment optical coherence tomography (AS-OCT) imaging (Avanti RTVue XR, Optovue).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!