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Hydrogel and scalp/skin conductivities impact dose from tumor treating fields.
Front Bioeng Biotechnol
February 2025
Brain Tumor Center & Neuro-Oncology Unit, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Purpose: Tumor Treating Fields (TTFields) are delivered by transducer arrays applied to scalp or body surface for treatment of multiple malignancies. Dermatologic complications are thought to be related to hydrogel situated between the electrodes and scalp or skin to facilitate electric field penetration. High intensity of TTFields on these surfaces may also be a contributing factor.
View Article and Find Full Text PDFModeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity?
Front Cardiovasc Med
February 2025
Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, CT, United States.
Thoracic aortic aneurysm and dissection (TAAD) significantly impact cardiovascular morbidity and mortality. A large subset of TAAD cases, particularly those with an earlier onset, is linked to heritable genetic defects. Despite progress in characterizing genes associated with both syndromic and non-syndromic heritable TAAD, the causative gene remains unknown in most cases.
View Article and Find Full Text PDFFifteen years of ChEMBL and its role in cheminformatics and drug discovery.
J Cheminform
March 2025
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB101SD, UK.
In October 2024 we celebrated the 15th anniversary of the first launch of ChEMBL, Europe's most impactful, open-access drug discovery database, hosted by EMBL's European Bioinformatics Institute (EMBL-EBI). This is a good moment to reflect on ChEMBL's history, the role that ChEMBL plays in Cheminformatics and Drug Discovery as well as innovations accelerated using data extracted from it. The review closes by discussing current challenges and possible directions that need to be taken to guarantee that ChEMBL continues to be the pioneering resource for highly curated, open bioactivity data on the European continent and beyond.
View Article and Find Full Text PDFEquitable machine learning counteracts ancestral bias in precision medicine.
Nat Commun
March 2025
Department of Computer & Information Science & Engineering, University of Florida, 1889 Museum Rd, Gainesville, 32611, FL, USA.
Gold standard genomic datasets severely under-represent non-European populations, leading to inequities and a limited understanding of human disease. Therapeutics and outcomes remain hidden because we lack insights that could be gained from analyzing ancestrally diverse genomic data. To address this significant gap, we present PhyloFrame, a machine learning method for equitable genomic precision medicine.
View Article and Find Full Text PDFAn Innovative Approach to Chin Ptosis Correction with Surgical Net.
Aesthetic Plast Surg
March 2025
Department of Plastic Surgery, University of California, Irvine, Orange, CA, USA.
Objective: Chin ptosis, characterized by the descent of soft tissues below the inferior mandibular border, significantly impacts lower facial aesthetics. Traditional facial rejuvenation procedures often fail to comprehensively address this condition. The surgical net technique offers a novel approach for precise repositioning and stabilization of the chin.
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