Ship pilotage constitutes a critical element of port safety, where the reliability of pilots is paramount to safeguarding the operational integrity and safety of both ports and vessels. Understanding the effectiveness of pilots under different levels of reliability is crucial for assessing pilotage safety. Therefore, this study first improves the cognitive reliability and error analysis method (CREAM) using decision-makingand evaluation experiment method (DEMATEL) and improved CPC factor influence rules. The enhanced CREAM method is subsequently employed to quantify human reliability. Furthermore, this study models the piloting process using the classical PID control framework and establishes a quantitative relationship between human reliability and PID parameters. Human reliability is considered as a factor influencing the control system, thus constructing a pilotage control model based on human reliability. To validate the model, this study utilizes ship arrival data from Qingdao Port to simulate two typical pilotage scenarios: straight-line and complex-path arrivals. The simulation evaluates the effectiveness of pilotage control across varying levels of reliability, reflecting different pilot performance scenarios. The results indicate that higher reliability leads to faster response times and smaller route errors. Specifically, pilotage response time for low-reliability scenarios is four times longer than that for high-reliability scenarios, and route error is twice as large as that for high-reliability scenarios.
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http://dx.doi.org/10.1038/s41598-025-93154-7 | DOI Listing |
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Department of Biochemistry and Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid, 47005 Valladolid, Spain.
Neurodegenerative diseases encompass a number of very heterogeneous disorders, primarily characterized by neuronal loss and a concomitant decline in neurological function. Examples of this type of clinical condition are Alzheimer's Disease, Parkinson's Disease, Huntington's Disease and Amyotrophic Lateral Sclerosis. Age has been identified as a major risk in the etiology of these disorders, which explains their increased incidence in developed countries.
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Metformin has been a cornerstone in the management of type 2 diabetes mellitus (T2DM) for more than 50 years, either alone or in combination with other therapies. This oral antihyperglycemic agent, also known as dimethylbiguanide, plays a crucial role in regulating noninsulin-dependent diabetes mellitus and is widely prescribed globally for various medical conditions. Recent advancements in its formulations have aimed to increase its effectiveness, tolerance, and nonglycemic effects.
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Accurate differentiation of homologous proteins that share high sequence identity remains a significant challenge in biomedical research, as conventional antibodies often lack sufficient specificity, leading to potential misinterpretations. This issue is particularly evident in the study of hexokinases, a family of isoenzymes that catalyze the first step of glycolysis by phosphorylating glucose. Beyond their canonical metabolic roles, hexokinases play critical non-glycolytic functions, especially in cancer biology.
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