This mini-review article presents a comprehensive update on recent advancements in blood pressure management, based on original research published between 2023 and 2024. As part of the "Hypertension Research 2024 Update and Perspectives", the review integrates insights from the JSH2024 Fukuoka Declaration, emphasizing the concept of "NEO-HYPERTENSION harmonized with society". The strategies proposed in this review aim to realize this concept by promoting lifelong blood pressure management, preemptive medicine, and leveraging digital health technologies. Key strategies include adherence to treatment guidelines, overcoming clinical inertia, and the utilization of new digital tools and novel antihypertensive agents. Additionally, the review explores the significance of multidisciplinary collaboration and non-pharmacological therapies, as well as the importance of setting individualized treatment goals tailored to patients' unique backgrounds. By aligning with the JSH's vision, this review offers a fresh perspective on contemporary clinical practices and future directions. These updates aim to contribute to improved patient outcomes and global health advancements in hypertension care.
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http://dx.doi.org/10.1038/s41440-025-02130-1 | DOI Listing |
Ther Apher Dial
March 2025
Nephrology Blood Purification Center, The First Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China.
Introduction: This study aimed to investigate the effect of intermittent hemodialysis filtration mode (IHDF) on intradialytic hypotension and nutritional status in patients with end-stage renal disease (ESRD).
Methods: Patients with ESRD who underwent hemodialysis and were treated at our hospital from December 2021 to December 2023 according to the inclusion and exclusion criteria were selected and randomly assigned into two groups: the experimental group (patients received intermittent hemodialysis filtration mode treatment, n = 50) and the control group (patients received conventional maintenance hemodialysis treatment, n = 49). Subsequently, the participant characteristics, the treatment effect, the occurrence of intradialytic hypotension, the safety assessment, blood pressure indicators, and the nutritional status were compared between the two groups.
Arterioscler Thromb Vasc Biol
March 2025
Department of Pediatrics, Division of Pediatric Cardiology, Medical College of Wisconsin, Milwaukee (T.B., J.R.K., A.J.K., J.L.).
Background: Heart valve function requires a highly organized ECM (extracellular matrix) network that provides the necessary biomechanical properties needed to withstand pressure changes during each cardiac cycle. Lay down of the valve ECM begins during embryogenesis and continues throughout postnatal stages when it is remodeled into stratified layers and arranged according to blood flow. Alterations in this process can lead to dysfunction and, if left untreated, heart failure.
View Article and Find Full Text PDFFront Immunol
March 2025
Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, Hubei, China.
Hypertension, a globally prevalent condition, is closely associated with T cell-mediated inflammatory responses. Studies have shown that T cells, by secreting pro-inflammatory cytokines such as interferon-gamma (IFN-γ), Interleukin-17 (IL-17), and Tumor necrosis factor-alpha (TNF-α), directly lead to vascular dysfunction and elevated blood pressure. The activation of Th1 and Th17 cell subsets, along with the dysfunction of regulatory T cells (Tregs), is a critical mechanism in the onset and progression of hypertension.
View Article and Find Full Text PDFAnesth Pain Med
October 2024
Anesthesiology Unit, Surgical Intensive Care and Pain Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Background: Modified rapid sequence intubation (RSI) is crucial in emergency surgery, particularly for patients with a full stomach, as it allows for the administration of general anesthesia (GA).
Objectives: This work aimed to evaluate mivacurium effectiveness and optimal dose in modified RSI.
Methods: This randomized double-blind study involved 100 patients, aged between 20 - 60 years, of both sexes, with the American Society of Anesthesiologists physical status classification of I - III, who were undergoing emergency surgery under GA.
Anesth Pain Med
October 2024
School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Background: Intraoperative bleeding is one of the major challenges in rhinoplasty.
Objectives: This study aimed to evaluate the effect of pressure-controlled ventilation (PCV) versus volume-controlled ventilation (VCV) modes on intraoperative bleeding during rhinoplasty.
Methods: In a double-blinded randomized clinical trial, 58 candidates for rhinoplasty were randomly assigned to the PCV or VCV groups.
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