Targeting drug-resistant Acinetobacter baumannii, two fungal strains, Epicoccum sp. 1-042 and Penicillium sp. 19-115, were identified from 35 fungi isolated from Tibet. Bioassay-guided isolation from Epicoccum sp. 1-042 yielded a novel cyclohexenone, epiconone (1), and parasitenone (2), while patulin (3) was isolated from Penicillium sp. 19-115. Structural elucidation was accomplished through comprehensive spectroscopic analysis and quantum chemistry calculations. The biosynthetic pathways of compounds 1 and 2 were proposed based on bioinformatics analysis. Compounds 1 - 3 exhibited antibacterial activity against carbapenem-resistant Acinetobacter baumannii (CRAB) with MIC values ranging from 4 to 128 μg mL.
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Epiconone, one novel cyclohexenone from endophytic fungi Epicoccum sp. 1-042.
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CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People's Republic of China.
Targeting drug-resistant Acinetobacter baumannii, two fungal strains, Epicoccum sp. 1-042 and Penicillium sp. 19-115, were identified from 35 fungi isolated from Tibet.
View Article and Find Full Text PDFBioactivity-Based Molecular Networking-Guided Isolation of Epicolidines A-C from the Endophytic Fungus sp. 1-042.
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CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tiantan xili No. 1, Beijing 100050, People's Republic of China.
Article Synopsis
- Researchers discovered three new compounds, epicolidines A-C, and one known compound, PF 1052, from an endophytic fungus in Tibet, utilizing bioactivity-based molecular networking-guided fractionation.
- The chemical structures of these compounds were determined through methods like spectroscopy, hydrolysis, quantum chemistry calculations, and X-ray diffraction.
- Notably, one compound showed strong antibacterial activity against vancomycin-resistant enterococci (VRE), with a minimum inhibitory concentration (MIC) of 0.25 μg/mL, outperforming a common antibiotic combination and achieving a 100% survival rate in a VRE infection model.
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