Polyvinyl alcohol (PVA)/polyethylene glycol (PEG) hydrogels, being low-cost and abundant materials, can demonstrate tremendous potential in applications requiring mechanical robustness by harnessing the enhancements afforded by a structure inspired by articular cartilage (AC). This study presents the fabrication of bioinspired PVA/PEG (BPP) hydrogel, characterized by their high mechanical strength and low friction coefficient. By utilizing a concrete-like structure composed of PVA particles and PVA/PEG fibers, the BPP hydrogel demonstrates notable properties such as high compressive strength (86%, 29.5 MPa), high tensile strength (265%, 10.5 MPa), fatigue resistance, impact resistance, and cut resistance. Moreover, under submerged conditions, it exhibits low coefficient of friction (COF) and minimal wear. The packaged hydrogel sensor demonstrates high sensitivity, high linearity, and fast response time. Ultimately, we endeavor to apply the straightforward yet competent bioinspired strategy to intelligent protective sensing equipment, showcasing extensive prospects for practical applications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889110 | PMC |
| http://dx.doi.org/10.1038/s41467-025-57653-5 | DOI Listing |
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Polyvinyl alcohol (PVA)/polyethylene glycol (PEG) hydrogels, being low-cost and abundant materials, can demonstrate tremendous potential in applications requiring mechanical robustness by harnessing the enhancements afforded by a structure inspired by articular cartilage (AC). This study presents the fabrication of bioinspired PVA/PEG (BPP) hydrogel, characterized by their high mechanical strength and low friction coefficient. By utilizing a concrete-like structure composed of PVA particles and PVA/PEG fibers, the BPP hydrogel demonstrates notable properties such as high compressive strength (86%, 29.
View Article and Find Full Text PDFA bioengineered hydrogel system enables targeted and sustained intramyocardial delivery of neuregulin, activating the cardiomyocyte cell cycle and enhancing ventricular function in a murine model of ischemic cardiomyopathy.
Circ Heart Fail
July 2014
From the Department of Cardiothoracic Surgery, Stanford University, CA (J.E.C., J.W.M., Y.S., J.B.P., B.B.E., Y.J.W.); and Departments of Surgery, Division of Cardiovascular Surgery (J.E.C., J.W.M., C.M.B., A.T., A.S.F., G.H., W.H., P.A.), Bioengineering (B.P.P., M.S.D., J.A.B.), and Cardiology (A.M., K.B.M.), University of Pennsylvania, Philadelphia.
Background: Neuregulin-1β (NRG) is a member of the epidermal growth factor family possessing a critical role in cardiomyocyte development and proliferation. Systemic administration of NRG demonstrated efficacy in cardiomyopathy animal models, leading to clinical trials using daily NRG infusions. This approach is hindered by requiring daily infusions and off-target exposure.
View Article and Find Full Text PDFSustained release of engineered stromal cell-derived factor 1-α from injectable hydrogels effectively recruits endothelial progenitor cells and preserves ventricular function after myocardial infarction.
Circulation
September 2013
Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA (J.W.M., Y.S., J.E.C., A.F., A.T., J.P., P.H., E.Y., K.L., W.H., P.A., Y.J.W.); and Department of Bioengineering, University of Pennsylvania, Philadelphia, PA (B.P.P., J.A.B.).
Background: Exogenously delivered chemokines have enabled neovasculogenic myocardial repair in models of ischemic cardiomyopathy; however, these molecules have short half-lives in vivo. In this study, we hypothesized that the sustained delivery of a synthetic analog of stromal cell-derived factor 1-α (engineered stromal cell-derived factor analog [ESA]) induces continuous homing of endothelial progenitor cells and improves left ventricular function in a rat model of myocardial infarction.
Methods And Results: Our previously designed ESA peptide was synthesized by the addition of a fluorophore tag for tracking.
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