Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11427-024-2863-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation.
Cells
March 2025
Department of Pathology, Hebei Medical University, Shijiazhuang 050017, China.
Diabetic kidney disease (DKD) is a prevalent complication associated with diabetes in which podocyte dysfunction significantly contributes to the development and progression of the condition. Ring finger protein 183 (RNF183) is an ER-localized, transmembrane ring finger protein with classical E3 ligase activity. However, whether RNF183 is involved in glomerular podocyte dysfunction, which is the mechanism of action of DKD, is still poorly understood.
View Article and Find Full Text PDFE3 ubiquitin ligase MARCH5 positively regulates Japanese encephalitis virus infection by catalyzing the K27-linked polyubiquitination of viral E protein and inhibiting MAVS-mediated type I interferon production.
mBio
March 2025
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Membrane-associated RING-CH-type finger (MARCH) proteins, a class of E3 ubiquitin ligases, have been reported to be involved in the infection of multiple viruses and the regulation of type I interferon (IFN) production. However, the specific role and mechanisms by which MARCH proteins influence Japanese encephalitis virus (JEV) infection remain poorly understood. Here, we systematically investigate the functional relevance of MARCH proteins in JEV replication by examining the effects of siRNA-mediated knockdown of MARCHs on viral infection.
View Article and Find Full Text PDFhsa_circ_0004846 enhances the malignant phenotype of papillary thyroid carcinoma cells via the miR‑142‑3p/PELI1 axis.
Oncol Lett
April 2025
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
Circular RNAs (circRNAs) are closely associated with human tumorigenesis; however, whether hsa_circ_0004846 serves a role in the progression of papillary thyroid carcinoma (PTC) remains unclear. Therefore, the present study aimed to investigate the effect of hsa_circ_0004846 on PTC. The results demonstrated that circ_0004846 was abnormally upregulated in PTC tissues and thyroid cancer cell lines (BCPAP, TPC-1 and IHH-4).
View Article and Find Full Text PDFWheat E3 ligase is involved in drought stress tolerance in transgenic .
Physiol Mol Biol Plants
February 2025
Department of Plant Resources, College of Industrial Sciences, Kongju National University, 54 Daehak-Ro, Yesan-Eup, 32439 Republic of Korea.
Unlabelled: , a wheat U-box E3 ligase gene, was isolated and characterized for its role in drought stress tolerance. The gene encodes a 531 amino acid protein with a U-box domain at the N-terminal and a WD40 domain at the C-terminal. Subcellular localization studies using TaPRP19-GFP fusion in confirmed predominant nucleus localization.
View Article and Find Full Text PDFThe deubiquitinase inhibitor WP1130 drives nuclear aggregation and reactivation of mutant p53 for selective cancer cell targeting.
FEBS J
March 2025
Cell and Tumor Biology Group, Teni Lab, Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Navi Mumbai, India.
Mutations in the TP53 gene may lead to the loss of its tumor suppressor function and the acquisition of oncogenic properties. The enhanced stability of mutant p53 (mutp53) is one of the pivotal factors for its oncogenic functions, rendering proteins implicated in mutp53 stabilization as promising targets for therapeutic intervention. Although deubiquitinases (DUBs) are commonly deregulated in various cancers, their specific impact on mutp53 stabilization remains largely unexplored.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!