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Role of Mahendra Maneuver in Sinusitis and Eustachian Tube Dysfunction.
Indian J Otolaryngol Head Neck Surg
January 2025
Indian Institute of Ear Diseases, Muzaffarnagar, Uttar Pradesh India.
The article titled "Role of the Maneuver in Sinusitis and Eustachian Tube Dysfunction" explores the efficacy of a novel technique known as the Maneuver. Sinusitis and Eustachian tube dysfunction are prevalent respiratory conditions often linked to impaired mucociliary flow and poor nasal clearance. Traditional maneuvers such as the Toynbee and Valsalva techniques provide temporary relief by forcefully opening the Eustachian tube but carry risks of injury and complications and does not work for sinusitis.
View Article and Find Full Text PDFSirt5 affects the metabolic remodeling of eosinophils by negatively regulating the level of succinylation modification of Pkm2 in eosinophilic chronic rhinosinusitis.
World J Otorhinolaryngol Head Neck Surg
March 2025
Objectives: This study aims to investigate the role of Sirt5 in regulating eosinophil maturation and activation, specifically focusing on primary eosinophils in mice at the genetic level. Additionally, the study aims to elucidate the underlying mechanism of Sirt5 in eosinophilic inflammation metabolism and identify potential drug targets for the treatment of chronic sinusitis. The findings of this study will provide new insights and a solid theoretical basis for the development of novel therapeutic strategies for eosinophilic chronic rhinosinusitis (eCRS).
View Article and Find Full Text PDFSLC37A3-associated retinitis pigmentosa: a case report of clinical features and three-year follow up.
Doc Ophthalmol
March 2025
Department of Ophthalmology, Vanderbilt Clinic, Columbia University Irving Medical Center, 622 W 168th St 3rd Floor, New York, NY, 10032, USA.
Purpose: To describe a case of SLC37A3-associated retinitis pigmentosa (RP) and associated imaging and electroretinography findings.
Methods: The patient was evaluated at Columbia University Irving Medical Center using a comprehensive multimodal imaging protocol that included color fundus photography, fundus autofluorescence (FAF), and spectral-domain optical coherence tomography. Functional assessments were conducted using full-field electroretinography (ERG), following the ISCEV standard protocols to ensure consistent and reproducible measurements of photoreceptor activity.
The virome investigation of the globally endangered Eld's deer (Rucervus eldii) on Hainan Island, China.
Sci Rep
March 2025
Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, 571199, China.
Eld's deer (Rucervus eldii) is a rare and globally endangered tropical Southeast Asian deer species. There is no research on pathogens in Eld's deer in Hainan, China. This study aimed to understand the virus diversity and novel viruses in Eld's deer, and provided important epidemiological baseline information for conservation of this endangered species.
View Article and Find Full Text PDFApplicability of Paediatric Kerrison's Punch in Endoscopic Transcanal Mastoidectomy-Harnessing a Fresh Perspective.
Indian J Otolaryngol Head Neck Surg
January 2025
Department of ENT, Mahatma Gandhi university of medical sciences and technology (MGUMST), Sitapura, Jaipur, Rajasthan India.
The science of endoscopic ear surgery is gaining popularity and increasing momentum with reported outcomes comparable to conventional microscopic ear surgery. Endoscopic ear surgery has numerous advantages including access to visualization of occult areas of middle ear like sinus tympani. The endoscopic transcanal mastoidectomy via conventional drilling technique(Inside-out) has also established itself as a successful procedure with excellent post-operative outcomes.
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