Pulmonary blastoma, a rare and aggressive primary lung tumour, poses diagnostic challenges due to its vague clinical presentation and rarity. Here, we outline the case of a chronic smoker in his 50s presenting with cough and blood-tinged sputum. Radiological assessment revealed a mass lesion in the left upper lobe. Despite inconclusive findings from a conventional Computed Tomography (CTguided biopsy, surgical resection ultimately led to the diagnosis of biphasic pulmonary blastoma. Subsequent histopathological examination and immunohistochemistry (IHC) confirmed the diagnosis, prompting the initiation of adjuvant chemotherapy postoperatively. This case emphasises the importance of thorough diagnostic evaluation, including histopathology and IHC, in guiding treatment decisions for pulmonary blastoma. Furthermore, it highlights the necessity for further research to establish optimal management approaches for this rare malignancy.
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http://dx.doi.org/10.1136/bcr-2024-263276 | DOI Listing |
BMJ Case Rep
March 2025
Respiratory Medicine, MS Ramaiah Medical College, Bengaluru, Karnataka, India.
Pulmonary blastoma, a rare and aggressive primary lung tumour, poses diagnostic challenges due to its vague clinical presentation and rarity. Here, we outline the case of a chronic smoker in his 50s presenting with cough and blood-tinged sputum. Radiological assessment revealed a mass lesion in the left upper lobe.
View Article and Find Full Text PDFJ Natl Cancer Cent
February 2025
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Background: Pulmonary blastoma (PB) is a rare subtype of lung cancer. Currently, the underlying pathogenesis mechanisms of PB have not been fully illustrated, and the therapeutic approach for this entity is limited.
Methods: Whole-exome sequencing (WES), RNA sequencing, and DNA methylation profiling are applied to seven PB patients.
Biology (Basel)
January 2025
Division of Thoracic Surgery, Cantonal Hospital Lucerne, 6000 Lucerne, Switzerland.
In 2001, two enzyme-encoding genes were recognized in the fruit fly . The genetic material, labeled and , encodes ribonuclease-type enzymes with slightly diverse target substrates. The human orthologue is .
View Article and Find Full Text PDFOncol Lett
March 2025
Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Pleuropulmonary blastoma (PPB) is an uncommon malignant neoplasm occurring in infants. The disease is intimately linked to mutations in the Dcr-1 homolog and ribonuclease type III (DICER1) genes. Imaging techniques are crucial for diagnosing PPB, yet distinguishing PPB from other pulmonary masses proves challenging.
View Article and Find Full Text PDFPediatr Blood Cancer
March 2025
Pediatric Hematology and Oncology Department, University Hospital of Caen, Caen, France.
Background And Aims: Primary lung tumors (PLTs) in children are rare, and surgery remains the key to ensure remission. Here we describe the PLTs clinical characteristics, their management, and the pulmonary outcome following surgery.
Methods: We carried out a French national cohort of pediatric PLTs from 2013 to 2023 from the FRACTURE rare pediatric tumors national database.
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