Adult pulmonary blastoma.

BMJ Case Rep

Respiratory Medicine, MS Ramaiah Medical College, Bengaluru, Karnataka, India.

Published: March 2025

Pulmonary blastoma, a rare and aggressive primary lung tumour, poses diagnostic challenges due to its vague clinical presentation and rarity. Here, we outline the case of a chronic smoker in his 50s presenting with cough and blood-tinged sputum. Radiological assessment revealed a mass lesion in the left upper lobe. Despite inconclusive findings from a conventional Computed Tomography (CTguided biopsy, surgical resection ultimately led to the diagnosis of biphasic pulmonary blastoma. Subsequent histopathological examination and immunohistochemistry (IHC) confirmed the diagnosis, prompting the initiation of adjuvant chemotherapy postoperatively. This case emphasises the importance of thorough diagnostic evaluation, including histopathology and IHC, in guiding treatment decisions for pulmonary blastoma. Furthermore, it highlights the necessity for further research to establish optimal management approaches for this rare malignancy.

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2024-263276DOI Listing

Publication Analysis

Top Keywords

pulmonary blastoma
16
adult pulmonary
4
blastoma
4
blastoma pulmonary
4
blastoma rare
4
rare aggressive
4
aggressive primary
4
primary lung
4
lung tumour
4
tumour poses
4

Similar Publications

Adult pulmonary blastoma.

BMJ Case Rep

March 2025

Respiratory Medicine, MS Ramaiah Medical College, Bengaluru, Karnataka, India.

Pulmonary blastoma, a rare and aggressive primary lung tumour, poses diagnostic challenges due to its vague clinical presentation and rarity. Here, we outline the case of a chronic smoker in his 50s presenting with cough and blood-tinged sputum. Radiological assessment revealed a mass lesion in the left upper lobe.

View Article and Find Full Text PDF

Integrated molecular characterization reveals the pathogenesis and therapeutic strategies of pulmonary blastoma.

J Natl Cancer Cent

February 2025

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Background: Pulmonary blastoma (PB) is a rare subtype of lung cancer. Currently, the underlying pathogenesis mechanisms of PB have not been fully illustrated, and the therapeutic approach for this entity is limited.

Methods: Whole-exome sequencing (WES), RNA sequencing, and DNA methylation profiling are applied to seven PB patients.

View Article and Find Full Text PDF

In 2001, two enzyme-encoding genes were recognized in the fruit fly . The genetic material, labeled and , encodes ribonuclease-type enzymes with slightly diverse target substrates. The human orthologue is .

View Article and Find Full Text PDF

Pleuropulmonary blastoma (PPB) is an uncommon malignant neoplasm occurring in infants. The disease is intimately linked to mutations in the Dcr-1 homolog and ribonuclease type III (DICER1) genes. Imaging techniques are crucial for diagnosing PPB, yet distinguishing PPB from other pulmonary masses proves challenging.

View Article and Find Full Text PDF

Background And Aims: Primary lung tumors (PLTs) in children are rare, and surgery remains the key to ensure remission. Here we describe the PLTs clinical characteristics, their management, and the pulmonary outcome following surgery.

Methods: We carried out a French national cohort of pediatric PLTs from 2013 to 2023 from the FRACTURE rare pediatric tumors national database.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!