We present a unique case of a 38-year-old man with 2 rare conditions: unicuspid aortic valve and polycythemia vera. The patient developed left ventricular hypertrophy, which showed regression after polycythemia vera treatment. This is the first reported case of left ventricular hypertrophy regression after polycythemia vera treatment.
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http://dx.doi.org/10.1016/j.jaccas.2024.103176 | DOI Listing |
Am J Hematol
March 2025
CRIMM, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Florence, Italy.
This paper explores emerging therapies in polycythemia vera and essential thrombocythemia, focusing on thrombosis as a driver of disease progression leading to myelofibrosis, blast phase, second cancers, and mortality. While the thrombosis rate in high-risk patients has declined, it remains persistently high in low-risk individuals, with most events being arterial. Inflammation driven by JAK2 V617F mutation plays a primary role in pathogenesis, and mounting evidence suggests arterial thrombosis itself can fuel a self-sustaining cycle of inflammation, thereby accelerating hematologic and systemic complications.
View Article and Find Full Text PDFEur J Cancer
January 2025
Analytical Epidemiology and Health Impact Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Background: EUROCARE, a European population-based cancer project, has shown geographical survival disparities for myeloid neoplasms (MN) suggesting healthcare inequalities. Total National Health Expenditure (TNHE) might influence population-based MN survival. We studied the long-term survival of 15 MN and the TNHE impact on prognosis between European countries.
View Article and Find Full Text PDFJACC Case Rep
March 2025
Department of Cardiology, Ascension St. Vincent Hospital, Indianapolis, Indiana, USA.
We present a unique case of a 38-year-old man with 2 rare conditions: unicuspid aortic valve and polycythemia vera. The patient developed left ventricular hypertrophy, which showed regression after polycythemia vera treatment. This is the first reported case of left ventricular hypertrophy regression after polycythemia vera treatment.
View Article and Find Full Text PDFPediatr Blood Cancer
March 2025
Hôpital Saint Louis, Paris, France.
Classical myeloproliferative neoplasms (MPNs) are being identified more frequently in adolescents. There is no guidance on the healthcare transition of young MPN patients from pediatric to adult medicine. Therefore, we convened an international panel of experts in both pediatric and adult MPN care to develop three tools to facilitate high-quality healthcare transition: a physician education tool, a transition readiness assessment tool, and a consensus statement of practice recommendations to ensure a more seamless transition in the care adolescents receive.
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