Background: Takayasu arteritis (TA) is a rare vasculitis affecting large vessels, predominantly in young women. Coronary artery involvement, although uncommon, significantly worsens the prognosis due to complications (eg, aneurysm formation, thrombosis), potentially leading to acute myocardial infarction.
Case Summary: A 27-year-old woman presented with fever, fatigue, and conjunctival erythema. One month later, she developed acute chest pain and dyspnea. Coronary angiography revealed giant coronary ectasia with right coronary artery thrombosis, and noninvasive imaging confirmed TA. The patient was treated with immunosuppressive therapy, antithrombotic agents, and multidisciplinary care, resulting in significant clinical improvement.
Take-home Message: TA with coronary involvement, particularly coronary aneurysms, is an extremely rare but clinically significant condition.
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| http://dx.doi.org/10.1016/j.jaccas.2024.103030 | DOI Listing |
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Highlights from the plenary session: clinically relevant outcomes.
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Vasculitis Unit of Vienna, Vienna, Austria.
The plenary session on clinically relevant outcomes in systemic vasculitis emphasized the significance of monitoring creatinine, haematuria and proteinuria for predicting renal outcomes, recovery of kidney function in severe ANCA glomerulonephritis and outcomes post-kidney transplantation in anti-glomerular basement membrane disease. These findings have the potential to enhance clinical practice by refining prognostication and treatment strategies. Future research gaps include exploring the predictive role of proteinuria and understanding the impact of different clinical phenotypes on disease outcomes in Takayasu arteritis.
View Article and Find Full Text PDFHighlights from the breakout session: imaging in disease assessment.
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Department of General Internal Medicine, UZ Leuven, Leuven, Belgium.
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View Article and Find Full Text PDFSingle-cell transcriptome analysis reveals cellular heterogeneity in the aortas of Takayasu arteritis.
Arthritis Res Ther
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Department of Rheumatology and Immunology, Capital Medical University Affiliated Anzhen Hospital, Beijing, China.
Objectives: Takayasu arteritis (TAK) is an inflammatory vasculitis that affects the aorta and its primary branches. The pathogenesis of TAK remains elusive, yet identifying key cell types in the aorta of TAK patients is crucial for uncovering cellular heterogeneity and discovering potential therapeutic targets.
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Biologic therapies for the treatment of large vessel vasculitis: A systematic review and meta-analysis.
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Department of Cardiovascular Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
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Analysis of proinflammatory cytokine responses in Takayasu arteritis.
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Department of Internal Medicine, Division of Rheumatology, Marmara University Faculty of Medicine, İstanbul, Türkiye.
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