Papillary fibroelastomas (PFEs) are the most common benign cardiac tumors, typically found on valvular surfaces but less frequently on extravalvular structures. Despite their benign nature, PFEs are associated with serious embolic events. This study analyzes 13 cases of pathology-proven PFEs in the left atrial appendage (LAA) and pulmonary vein ridge. Data on patient demographics, clinical presentations, imaging, and histopathology were reviewed. The median patient age was 73 years, with slight male predominance. Tumor sizes ranged from 2 mm to 20 mm. Twelve PFEs were detected via transesophageal echocardiography, and neurologic events were observed in 4 patients. This case series emphasizes the importance of maintaining a broad differential diagnosis for LAA masses because PFEs can easily be mistaken for thrombi.
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http://dx.doi.org/10.1016/j.jaccas.2024.103192 | DOI Listing |
Echocardiography
March 2025
Coronary Unit, Ignacio Chávez National Institute of Cardiology, Mexico City, Mexico.
Take home messages 1. Despite being considered a benign tumor, the high reported incidence of embolic events increasingly warrants surgical resection, regardless of size, especially in patients with a history of cardiovascular risk factors. 2.
View Article and Find Full Text PDFJACC Case Rep
March 2025
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Papillary fibroelastomas (PFEs) are the most common benign cardiac tumors, typically found on valvular surfaces but less frequently on extravalvular structures. Despite their benign nature, PFEs are associated with serious embolic events. This study analyzes 13 cases of pathology-proven PFEs in the left atrial appendage (LAA) and pulmonary vein ridge.
View Article and Find Full Text PDFEur J Case Rep Intern Med
February 2025
Department of Life, Health and Environmental Science, University of L'Aquila, Italy.
Introduction: A case of fibroelastoma of the aortic valve in a patient with acute coronary syndrome has been reported. Cardiac papillary fibroelastomas (PFE) are rare cardiac tumours that are generally benign. In most cases they are incidental findings, their first clinical manifestation is often associated with embolic events.
View Article and Find Full Text PDFTrends Cardiovasc Med
February 2025
Department of Cardio-Thoracic Surgery, Maastricht University Medical Centre, Maastricht University, Maastricht, The Netherlands; Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.
This review article - which is devoted to a wide range of physicians, e.g., pathologists, clinicians, radiologists, and general practitioners - is an up-to-date clinico-pathological description of cardiac tumours.
View Article and Find Full Text PDFCardiol Young
February 2025
Hacettepe University Faculty of Medicine, Pediatric Cardiovascular Surgery, Turkey.
Approximately 90% of primary paediatric cardiac tumours are benign lesions. Depending on their location and size, benign cardiac tumours may cause inflow and outflow obstructions, cyanosis, valvular insufficiencies, myocardial ischaemia, associated dysfunction, systemic embolisation, arrhythmias, and even sudden death. Decision-making and timing for surgery can be challenging in children.
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