The case concerns a 20-year-old patient with Canadian Cardiovascular Society class II angina who was initially referred for aortic valve replacement because of a suspected high-grade aortic valve stenosis with increased transvalvular gradients (max/mean: 70/40 mm Hg) measured by Doppler echocardiography. Examinations using transesophageal echocardiography and computed tomography showed a sufficiently opening bicuspid aortic valve, excluded supra- and subvalvular stenoses, and measured a narrow aorta (diameter: 2 cm). The explanation for the highly increased gradients across the aortic valve was the pressure recovery (PR) phenomenon, which cannot be detected by Doppler gradients. Distal to a stenosis kinetic energy is converted back into potential energy, most effectively in small aortas (area: <3 cm). This reduces the actual transvalvular pressure gradient, which can directly be determined with cardiac catheterization. Accordingly, invasive measurements showed a moderate aortic stenosis (mean transvalvular pressure: 19 mm Hg), almost identical to the PR-corrected Doppler measurements. A high-grade stenosis of the proximal left anterior descending artery was treated interventionally, which could explain the angina symptoms.
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http://dx.doi.org/10.1016/j.jaccas.2024.103071 | DOI Listing |
J Am Coll Cardiol
March 2025
Cedars Sinai Medical Center, Los Angeles, California, USA. Electronic address:
This updated Heart Valve Collaboratory framework addresses the growing concern for transcatheter valve failure (TVF) following transcatheter aortic valve replacement (TAVR). With the increasing volume of redo-TAV and surgical TAV explantation, there is a critical need for standardized pathways and protocols for evaluating TVF using echocardiography and cardiac computed tomography (CT) angiography. This document clarifies prior definitions of bioprosthetic valve deterioration and bioprosthetic valve failure in a practical, imaging directed context for TAVR.
View Article and Find Full Text PDFCan J Cardiol
March 2025
Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel; The Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Background: The use of transcatheter aortic valve implantation (TAVI) for severe aortic stenosis is expanding to patients across the entire spectrum of surgical risk. We aimed to perform a meta-analysis comparing TAVI and surgical aortic valve replacement (SAVR) in trials enrolling lower risk patients.
Methods: We conducted a meta-analysis of randomized controlled trials (RCTs) comparing safety and efficacy outcomes between TAVI and SAVR among lower risk patients (mean/median STS score <4).
Int J Cardiol
March 2025
Division of Cardiology, Yale University School of Medicine, Bridgeport Hospital, Bridgeport, CT, USA.
Background: Transcatheter Aortic Valve Implantation (TAVI) has become the routine standard of care in patients with severe aortic stenosis and prohibitive surgical risk worldwide. However, data on TAVI outcomes from Africa remain sparse. This study aimed to evaluate the outcomes of TAVI in Africa.
View Article and Find Full Text PDFSci Adv
March 2025
Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Aortic valve stenosis (AVS) is a progressive disease, wherein males more often develop valve calcification relative to females that develop valve fibrosis. Valvular interstitial cells (VICs) aberrantly activate to myofibroblasts during AVS, driving the fibrotic valve phenotype in females. Myofibroblasts further differentiate into osteoblast-like cells and produce calcium nanoparticles, driving valve calcification in males.
View Article and Find Full Text PDFJACC Case Rep
January 2025
Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:
Background: Although rare, embolization of left atrial appendage occlusion (LAAO) devices carries a significant morbidity and mortality burden.
Case Summary: An asymptomatic 77-year-old woman with inability to tolerate anticoagulation due to gastrointestinal bleeding presented for 45-day transesophageal echocardiography following LAAO with a Watchman device, which demonstrated incidental device migration to the left ventricular outflow tract (LVOT). Percutaneous extraction was performed using a novel technique with rat tooth/alligator forceps to successfully retrieve the Watchman from the LVOT using a transaortic approach.
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