Background: There is no consensus on the preferred conduit for right ventricular outflow tract (RVOT) reconstruction for congenital cardiac disease.
Case Summary: We present a case of a 21-year-old woman with history of tetralogy of Fallot presenting with recurrent graft thrombosis and pulmonary emboli in the setting of RVOT reconstruction with a 20-mm expanded polytetrafluoroethylene (ePTFE) valved conduit (GORE PV1, W.L. Gore & Associates). A diagnosis of chronic thromboembolic pulmonary hypertension was made, and the patient underwent pulmonary endarterectomy and conduit exchange with a pulmonary homograft.
Discussion: The novelty and clinical significance of this report lies in the confirmation of thrombosis of a large-diameter ePTFE valved pulmonary conduit (20 mm) and its implications for monitoring and need for further optimization of thromboprophylaxis strategies in this population.
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http://dx.doi.org/10.1016/j.jaccas.2024.103069 | DOI Listing |
Epilepsia
March 2025
University of California San Francisco Weill Institute for Neurosciences, Benioff Children's Hospital, San Francisco, California, USA.
Objective: We analyzed the long-term safety and effectiveness of fenfluramine (FFA) in patients with Dravet syndrome (DS) in an open-label extension (OLE) study after participating in randomized controlled trials (RCTs) or commencing FFA de novo as adults.
Methods: Patients with DS who participated in one of three RCTs or were 19 to 35 years of age and started FFA de novo were included. Key endpoints were: incidence of treatment-emergent adverse events (TEAEs) in the safety population, and median percentage change in monthly convulsive seizure frequency (MCSF) from the RCT baseline to end of study (EOS) in the modified intent-to-treat (mITT) population.
J Asian Nat Prod Res
March 2025
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou510120, China.
Acute lung injury (ALI) has high morbidity and mortality. Lifei Qingchang Tang (LFQCT), a traditional Chinese medicine, has antioxidant and anti-inflammatory properties but its mechanism in ALI remains unclear. , LFQCT reduced intracellular Ca, ROS, and NO in LPS-induced RAW 264.
View Article and Find Full Text PDFImportance: Exercise intervention studies have shown benefits for patients with lung cancer undergoing surgery, yet most interventions to date have been resource intensive and have followed a one-size-fits-all approach.
Objective: To determine whether a personalized, clinic-aligned perioperative exercise program with remote monitoring and instructions can improve physical function and fatigue among patients undergoing surgery for lung cancer.
Design, Setting, And Participants: The Precision-Exercise-Prescription (PEP) randomized clinical trial is a single-center phase 3 trial.
Cytotherapy
February 2025
Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China. Electronic address:
Asthma, a prevalent allergic disease affecting approximately 300 million individuals globally, remains a significant public health challenge. Mesenchymal stromal cells (MSCs) and hepatocyte growth factor (HGF), both recognized for their immunomodulatory properties, hold therapeutic potential for asthma. However, their precise mechanisms remain underexplored.
View Article and Find Full Text PDFAm J Kidney Dis
March 2025
Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:
Critically ill patients that require kidney replacement therapy (KRT) are among the most ill and complex patients routinely encountered in the intensive care unit (ICU). Continuous KRT (CKRT) is used across many ICUs as the therapy of choice for hemodynamically unstable patients with kidney failure. Though existing trials have not shown superior survival or kidney recovery with CKRT relative to intermittent KRT, CKRT has largely become the standard of care in developed nations for the treatment of acute kidney injury (AKI) in patients with shock, acute brain injury, acute liver failure, and other forms of critical illness.
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