Polyetheretherketone (PEEK) has emerged as a promising material for bone substitution; however, its limited osseointegration hinders its clinical applications. This research employs a porous structural design alongside surface modification techniques to improve the osseointegration properties of PEEK. Porous PEEK scaffolds were fabricated via 3D printing technology, followed by the application of a stable coating of Yoda1-loaded methacrylated gelatin (GelMA) on their surfaces. After modification, the hydrophilicity of the PEEK scaffolds was considerably improved, and the GelMA coating facilitated the sustained release of Yoda1. In vitro experiments demonstrated that the modified surfaces promoted cell proliferation and adhesion, facilitated angiogenesis, and enhanced osteoblast differentiation and mineral deposition. Furthermore, porous PEEK scaffolds were implanted into the femoral condyles of SD rats for 6 weeks to evaluate in vivo osseointegration The results showed that the tailored three-dimensional porous structure, along with the Yoda1-loaded GelMA coating, promoted bone ingrowth and enhanced osseointegration within the scaffold. This study offers a viable strategy for enhancing PEEK osseointegration through a combination of structural design and surface modification, and introduces new avenues for the application of Yoda1 in bone tissue engineering.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijbiomac.2025.141577 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of substrate on the response of 3-dimensional periodontal ligament tissue to compressive stimulation.
J Oral Sci
March 2025
Department of Orthodontics, Osaka Dental University.
Purpose: The purpose of this study was to investigate the influence of substrates under the three-dimensional periodontal ligament (3D PDL) tissue on its biological functions after compressive stimulation.
Methods: A 3D PDL tissue was created using a poly(L-lactic acid) (PLLA) porous scaffold impregnated with human periodontal ligament fibroblasts (hPDLFs). It was then placed on a polyetheretherketone (PEEK) substrate, which has a comparable elastic modulus to bone and was compressed (25 g/cm) for 1, 3, and 7 days.
3D printed porous PEEK scaffolds with stable and durable gelatin composite hydrogel coating loaded Yoda1 for in vivo osseointegration.
Int J Biol Macromol
March 2025
School of Medicine, Nankai University, Tianjin 300071, China; Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China. Electronic address:
Polyetheretherketone (PEEK) has emerged as a promising material for bone substitution; however, its limited osseointegration hinders its clinical applications. This research employs a porous structural design alongside surface modification techniques to improve the osseointegration properties of PEEK. Porous PEEK scaffolds were fabricated via 3D printing technology, followed by the application of a stable coating of Yoda1-loaded methacrylated gelatin (GelMA) on their surfaces.
View Article and Find Full Text PDFPersonalised 3D-printed bioactive peek bone plate scaffold for treating femoral defects.
RSC Adv
February 2025
Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University Lanzhou Gansu Province 730070 China
Fractures affect millions of individuals worldwide, particularly those with osteoporosis, and often require rigid fixation for proper healing. Although traditional metal bone plates are effective, they are limited by their stiffness and inability to conform precisely to anatomical structures, leading to complications such as stress shielding and delayed healing. In this study, we utilized computer-aided design (CAD) combined with reverse engineering to develop a 3D bone plate scaffold model that perfectly matches the contours of the rabbit femur.
View Article and Find Full Text PDFContinuous Hyaluronic Acid Supply by a UHMWPE/PEEK Interlocking Scaffold for Metatarsophalangeal Joint Prosthesis Lubricating Applications.
ACS Appl Mater Interfaces
February 2025
School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, P.R. China.
Wear is one of the main causes of prothesis failure in hemiarthroplasty of small joints such as the metatarsophalangeal joint, to which lubrication improvement is a promising solution. Inspired by the natural joint structure and lubrication mechanisms, we developed a novel composite strategy for metatarsophalangeal joint hemiarthroplasty. An ultrahigh-molecular-weight polyethylene (UHMWPE) lubrication layer is interlocked within a 3D-printed poly(ether ether ketone) (PEEK) scaffold, and hyaluronic acid (HA) is introduced for hydrophilic modification of the UHMWPE matrix.
View Article and Find Full Text PDFSynergistic enhancement of angiogenesis and osseointegration in 3D-printed porous polyetheretherketone scaffolds using biomimetic coatings of bone morphogenetic protein-2/fibronectin.
Int J Biol Macromol
March 2025
Department of Stomatology, China-Japan Union Hospital of Jilin University, Changchun 130033, China. Electronic address:
This study explored a novel modification method for porous polyetheretherketone (PEEK) implants using a biomimetic coating to achieve synergistic enhancement of vascularization and bone regeneration. Inspired by the natural extracellular matrix (ECM) structure (consists of growth factors and matrix proteins), a biomimetic dual-factor coating capable of releasing bone morphogenetic protein-2 (BMP-2) and fibronectin (FN) was coated on the surface of 3D-printed porous PEEK scaffolds using polydopamine (PDA) as a binder. Experiments conducted with MC3T3-E1 cells or HUVECs in co-culture with scaffolds revealed that the biomimetic coating not only synergically promoted cell migration, adhesion and proliferation, but also enhanced angiogenesis and osteogenic differentiation simultaneously in vivo.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!