Patulin (PAT), a toxic fungal metabolite, can directly damage the intestinal barrier and gut homeostasis via altering microbiota composition. Although there are several attempts for the control of PAT in vitro, there are currently few studies on the improvement of intestinal damage caused by patulin using in vivo assay. In this study, a nanoparticle formulation of spherical bacterial cellulose was obtained by dynamic fermentation of Acetobacter xylinum to prepare bacterial cellulose nanoparticles (BCNs) and then modified with 3-mercaptotetraethoxysilane to produce BCN(SH), to increase PAT adsorption in vitro. Meanwhile, results revealed that BCN(SH)s protected the small intestinal microbial barrier and can be used by microorganisms, such as Bacteroides, Firmicutes, and Actinomycetes, to produce short-chain fatty acids (SCFAs). BCN(SH)s appears as a promising edible material that can be used to alleviate intestinal damage from patulin, and has yet to be tested in other gut intoxication models.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.toxicon.2025.108310 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Up IGF-I via high-toughness adaptive hydrogels for remodeling growth plate of children.
Regen Biomater
January 2025
Department of Orthopedics, National Children's Medical Center & Children's Hospital of Fudan University, Shanghai 201102, P. R. China.
The growth plate is crucial for skeletal growth in children, but research on repairing growth plate damage and restoring growth is limited. Here, a high-toughness adaptive dual-crosslinked hydrogel is designed to mimic the growth plate's structure, supporting regeneration and bone growth. Composed of aldehyde-modified bacterial cellulose (DBNC), methacrylated gelatin (GelMA) and sodium alginate (Alg), the hydrogel is engineered through ionic bonding and Schiff base reactions, creating a macroporous structure.
View Article and Find Full Text PDFKombucha Bacterial Cellulose: A Promising Biopolymer for Advanced Food and Nonfood Applications.
Foods
February 2025
Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil.
The pellicle is a coproduct of kombucha beverage production without economic value. This material is based on cellulose produced from bacteria and has better physical properties than cellulose isolated from plants. This review systematically analyzed the research literature about pellicle (KBC-kombucha bacteria cellulose) valorization.
View Article and Find Full Text PDFGreen Fabrication of Zinc-Based Metal-Organic Frameworks@Bacterial Cellulose Aerogels via In Situ Mineralization for Wastewater Treatment.
Molecules
February 2025
Shandong Provincial Key Laboratory of Microbial Engineering, Department of Bioengineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China.
Compared to conventional adsorbents, zinc-based metal-organic frameworks (MOFs) such as zeolite imidazolium skeleton-8 (ZIF-8) exhibit enhanced thermal, chemical, and structural stability. Nonetheless, their powdered form results in limited dispersibility in aqueous solutions and a tendency to aggregate, which significantly restricts their utility in adsorption applications. This study reports a green composite aerogel through the in situ mineralization of ZIF-8 onto bacterial cellulose (BC) for the effective removal of toxic metal ions (Cu) and Congo red (CR) from wastewater.
View Article and Find Full Text PDFDevelopment and Characterization of Antimicrobial Chitosan/Polyethylene Oxide/Bacterial Cellulose Nanofibers.
Polymers (Basel)
March 2025
Center for Nanotechnology and Biomaterials Application and Research (NBUAM), Marmara University, Istanbul 34722, Turkey.
This study introduces novel chitosan (CS) and polyethylene oxide (PEO) copolymers reinforced with bacterial cellulose (BC) to fabricate nanofibers using the electrospinning method. SEM analysis confirmed uniform nanofiber formation, with CS/PEO/BC nanofibers (~240 nm) exhibiting a larger diameter than CS/PEO ones (~190 nm). FTIR spectroscopy confirmed BC integration, while Differential scanning calorimetry analysis indicated minimal impact on glass transition temperature.
View Article and Find Full Text PDFBioactive bacterial cellulose/chitosan/sodium alginate composite film functionalized with Moringa oleifera seed extract: Antimicrobial, anticancer, and molecular docking studies.
Int J Biol Macromol
March 2025
Cellulose and Paper Department, National Research Centre, El-Tahrir St., Dokki, 12622 Giza, Egypt. Electronic address:
In this study, composite films (BC/Ch/SA/EEMS) were fabricated using the casting method by incorporating bacterial cellulose (BC), chitosan (Ch), and sodium alginate (SA) with ethanolic Moringa seed extract (EEMS). HPLC analysis detected 16 polyphenolic compounds in EEMS, with Rutin (59.56 μg/mL) the most abundant, while GC-MS analysis identified 11-octadecenoic acid (88.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!