Objectives: InternalBrace™ technique (Arthrex, Naples, USA) has been applied in anterior cruciate ligament repairs in recent years as an alternative to the anterior cruciate ligament reconstruction, with several advantages. The present paper aimed to investigate the optimal location to place the InternalBrace during surgery to reduce the stress on the repaired anterior cruciate ligament.
Methods: In silico study of a finite element model of the knee and the anterior cruciate ligament was developed to test the position of the InternalBrace at the repaired anterior cruciate ligament. Five different InternalBrace positions inside the anterior cruciate ligament were analyzed under two conditions: with and without damage. Stress and strain in both the InternalBrace and the anterior cruciate ligament were evaluated and compared with a healthy condition (without InternalBrace). The computational simulations using the finite element method were performed under predefined boundary conditions observed during anterior cruciate ligament tears.
Results: The peak strain (8.1%) was obtained in the damaged anterior cruciate ligament compared with a 4.8% strain in the undamaged anterior cruciate ligament in the case without InternalBrace with the same boundary conditions applied. The use of InternalBrace showed a decrease in the deformations of the anterior cruciate ligament, mainly when the InternalBrace was applied in the anteromedial bundle or crossed from the anterior cruciate ligament anteromedial tibial footprint to posterolateral femoral footprint.
Conclusion: The InternalBrace placement through the anteromedial bundle or crossed from the anteromedial tibial footprint to posterolateral femoral footprint showed the lowest peak stress and peak strain in the anterior cruciate ligament, with forces and deformation in the anterior cruciate ligament being partially shifted to the InternalBrace.
Level Of Evidence: Level V.
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http://dx.doi.org/10.1016/j.jisako.2025.100847 | DOI Listing |
J Pediatr Orthop
March 2025
Orthopédie Traumatologie, Hôpital des Enfants, CHU de Toulouse, Toulouse, France.
Background: Pediatric anterior cruciate ligament reconstruction (ACLR) in skeletally immature patients is still controversially debated, with several gaps in its literature. More information is needed about the role of concomitant meniscal injuries in postoperative outcomes and return to pre-injury sports level (RTS).
Methods: Fifty skeletally immature patients who underwent ACLR were enrolled prospectively: 21 had meniscal injury additionally, and 29 did not.
J Orthop Res
March 2025
Laboratory for Joint Tissue Repair and Regeneration, Orthopedic Soft Tissue Research Program, The Hospital for Special Surgery, New York, New York, USA.
The tendon graft is known to undergo a remodeling process after anterior cruciate ligament (ACL) reconstruction. However, little is known about the transcriptional profile of this process. The aim of the present study is to identify differentially expressed genes inside the remodeling ACL graft in the early phase after ACL reconstruction in our murine model using RNA sequencing (RNAseq).
View Article and Find Full Text PDFJ Bone Joint Surg Am
March 2025
Department of Sports Medicine, Peking University Third Hospital, Beijing, People's Republic of China.
Background: Identifying patients at high risk for failure of primary anterior cruciate ligament reconstruction (ACLR) on the basis of preoperative magnetic resonance imaging (MRI) measurements has received considerable attention. In this study, we aimed to identify potential risk factors for primary ACLR failure from preoperative MRI measurements and to determine optimal cutoff values for clinical relevance.
Methods: Retrospective review and follow-up were conducted in this nested case-control study of patients who underwent primary single-bundle ACLR using hamstring tendon autograft at our institution from August 2016 to January 2018.
Purpose: To analyze whether magnetic resonance imaging (MRI) can predict return to sport after anterior cruciate ligament (ACL) reconstruction and whether a correlation exists between return to sports, level of activity and MRI signals.
Methods: The search terms selected for inclusion in the title, abstract, and keyword fields were as follows: 'anterior cruciate ligament' OR 'ACL' AND 'graft maturation' OR 'MRI' AND 'return to sport' OR 'sports activity.' For each study, patient data and the MRI protocol used to assess graft maturation were extracted.
Objective: Translation of biological insights from preclinical studies to human disease is a pressing challenge in biomedical research, including in osteoarthritis. Translatable Components Regression (TransComp-R) is a computational framework that has previously been used to synthesize preclinical and human OA data to identify biological pathways predictive of human disease conditions. We aimed to evaluate the translatability of two common murine models of post-traumatic osteoarthritis - surgical destabilization of the medial meniscus (DMM) and noninvasive anterior cruciate ligament rupture (ACLR) - to transcriptomics cartilage data from human OA outcomes.
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