Many of us were taught in school that a small percentage of US cattle had bovine leukemia virus (BLV), and its impact was so small that control was not necessary. A lot has changed. Bovine leukemia virus has spread and now infects almost half of US dairy cattle and about a third of our beef cattle. We have learned that BLV disrupts immune function and can indirectly reduce milk production and shorten cow lifespan. Recent claims of human health risks need to be evaluated, and animal welfare aspects must be addressed. These issues will become more important as the dairy industry competes with nondairy alternatives. Fortunately, 2 new BLV control methods are made possible by a new diagnostic test that measures each cow's shedding of infectious particles. Control is possible by culling the usually small minority of cows that are responsible for most of the transmission. The genetic linkage to high BLV shedding has been found to be remarkably strong, and it is anticipated that animal breeders will soon start offering sires with alleles associated with low-level BLV shedding.
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http://dx.doi.org/10.2460/javma.24.12.0784 | DOI Listing |
Animals (Basel)
February 2025
School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
This work explored whether supplementing recombinant human interleukin-6 (IL6), interleukin-11 (IL11), or leukemia inhibitory factor (LIF) improves IVP bovine embryo development, morphology, and cryosurvivability. Embryos were treated from day 5 to 8 post-fertilization with either the carrier only (control) or 100 ng/mL of IL6, IL11, or LIF. Blastocyst formation and stage were determined on day 7 and 8.
View Article and Find Full Text PDFBMC Cancer
March 2025
School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science & Technology, Vandalur, Chennai, 600048, India.
Background: Universally, Allium ascalonicum (Shallots) is a well-known flavouring agent in many cuisines. Though, it's been proved for its health benefits due to the presence of alkaloids, flavonoids, terpenoids, phenols and coumarins, its role as an anti-neoplastic agent still requires comprehensive investigation. In our study, we have investigated the presence of potential anti-neoplastic phytocompounds, anti-inflammatory, cytotoxicity and anti-metastatic activity of Shallots against Triple-Negative Breast Cancer cell line, MDA-MB-231.
View Article and Find Full Text PDFMany of us were taught in school that a small percentage of US cattle had bovine leukemia virus (BLV), and its impact was so small that control was not necessary. A lot has changed. Bovine leukemia virus has spread and now infects almost half of US dairy cattle and about a third of our beef cattle.
View Article and Find Full Text PDFVirology
February 2025
Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto 860-8556, Japan. Electronic address:
The δ-retrovirus genus includes human T-cell leukemia viruses (HTLV-1, HTLV-2, HTLV-3), simian T-lymphotropic viruses (STLV), and bovine leukemia viruses (BLV), which establish lifelong, typically asymptomatic, infections. However, HTLV-1 and BLV can lead to leukemia or lymphoma in 2-5% of infected hosts after prolonged latency. HTLV-1, the first identified human oncogenic retrovirus, drives T-cell leukemia/lymphoma via cell-intrinsic mechanisms.
View Article and Find Full Text PDFBraz J Biol
February 2025
Universidade do Estado de Santa Catarina - UDESC, Departamento de Produção Animal, Lages, SC, Brasil.
Enzootic Bovine Leukosis (EBL), is infectious disease affecting especially older animals, although animals of all ages can be infected with the Bovine Leukemia Virus (BLV). Crioula Lageana is a locally adapted, rustic and long-lived bovine breed, important as a genetic resource. However, little is known about its health status, making it difficult to preserve the breed.
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