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http://dx.doi.org/10.1093/eurheartj/ehaf112 | DOI Listing |
Healthcare (Basel)
March 2025
Department of Emergency Medicine, Peking University Third Hospital, Beijing 100191, China.
The perceptions of practicing physicians regarding the current situation and appropriateness of shared decision-making (SDM) in life-sustaining treatment (LST) are of essential importance. The objective of this study is to investigate the clinical practice patterns and barriers to this process in China. A cross-sectional survey of physicians in China was conducted to assess perceived practices of SDM in LST.
View Article and Find Full Text PDFInt J Mol Sci
March 2025
School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China.
Atherosclerosis (AS) is a disease characterised by the accumulation of atherosclerotic plaques on the inner walls of blood vessels, resulting in their narrowing. In its early stages, atherosclerosis remains asymptomatic and undetectable by conventional pathological methods. However, as the disease progresses, it can lead to a series of cardiovascular diseases, which are a leading cause of mortality among middle-aged and elderly populations worldwide.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, South China Normal University, Guangzhou 510631, China.
As the blood-brain barrier (BBB) prevents molecules from accessing the central nervous system (CNS), the traditional systemic delivery of chemical drugs limits the development of neurological drugs. However, in recent years, innovative therapeutic strategies have tried to bypass the restriction of traditional drug delivery methods. In vivo gene therapy refers to emerging biopharma vectors that carry the specific genes and target and infect specific tissues; these infected cells and tissues then undergo fundamental changes at the genetic level and produce therapeutic proteins or substances, thus providing therapeutic benefits.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Department of Sport Biochemistry, School of Sport Science, Beijing Sport University (BSU), Beijing 100084, China.
Overweight patients with cardiovascular disease (CVD) tend to survive longer than normal-weight patients, a phenomenon known as the "obesity paradox". The phenotypic characteristics of adipose distribution in these patients (who survive longer) often reveal a larger proportion of subcutaneous white adipose tissue (scWAT), suggesting that the presence of scWAT is negatively associated with all-cause mortality and that scWAT appears to provide protective benefits in patients facing unhealthy states. Exercise-mediated browning is a crucial aspect of the benign remodeling process of adipose tissue (AT).
View Article and Find Full Text PDFDiagnostics (Basel)
February 2025
Department of Radiology, Jichi Medical University Saitama Medical Center, Saitama 330-0834, Japan.
Cardiovascular inflammation has recently emerged as a critical issue across various cardiovascular diseases. Various non-invasive imaging modalities are applied for assessing cardiovascular inflammation. Positron emission tomography (PET) using F-fluorodeoxyglucose (FDG) is a valuable non-invasive imaging tool for identifying active cardiovascular inflammation.
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