How to aggregate spatial-temporal information plays an essential role in video super-resolution (VSR) tasks. Despite the remarkable success, existing methods adopt static convolution to encode spatial-temporal information, which lacks flexibility in aggregating information in large-scale remote sensing scenes, as they often contain heterogeneous features (e.g., diverse textures). In this paper, we propose a spatial feature diversity enhancement module (SDE) and channel diversity exploration module (CDE), which explore the diverse representation of different local patterns while aggregating the global response with compactly channel-wise embedding representation. Specifically, SDE introduces multiple learnable filters to extract representative spatial variants and encodes them to generate a dynamic kernel for enriched spatial representation. To explore the diversity in the channel dimension, CDE exploits the discrete cosine transform to transform the feature into the frequency domain. This enriches the channel representation while mitigating massive frequency loss caused by pooling operation. Based on SDE and CDE, we further devise a multi-axis feature diversity enhancement (MADE) module to harmonize the spatial, channel, and pixel-wise features for diverse feature fusion. These elaborate strategies form a novel network for satellite VSR, termed MADNet, which achieves favorable performance against state-of-the-art method BasicVSR++ in terms of average PSNR by 0.14 dB on various video satellites, including JiLin-1, Carbonite-2, SkySat-1, and UrtheCast. Code will be available at https://github.com/XY-boy/MADNet.
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http://dx.doi.org/10.1109/TIP.2025.3547298 | DOI Listing |
Proc Natl Acad Sci U S A
March 2025
Department of Biomedical Engineering, and Center for Advanced Genomic Technologies, Duke University, Durham, NC 27708.
CRISPR-Cas9 systems have revolutionized biotechnology, creating diverse new opportunities for biomedical research and therapeutic genome and epigenome editing. Despite the abundance of bacterial CRISPR-Cas9 systems, relatively few are effective in human cells, limiting the overall potential of CRISPR technology. To expand the CRISPR-Cas toolbox, we characterized a set of type II CRISPR-Cas9 systems from select bacterial genera and species encoding diverse Cas9s.
View Article and Find Full Text PDFBreast cancer is the most prevalent cancer among women and poses a significant global health challenge due to its association with uncontrolled cell proliferation. Artificial intelligence (AI) integration into medical practice has shown promise in boosting diagnosis accuracy and treatment protocol optimisation, thus contributing to improved survival rates globally. This paper presents a comprehensive analysis utilizing the Wisconsin Breast Cancer dataset, comprising data from 569 patients and 30 attributes.
View Article and Find Full Text PDFBrief Bioinform
March 2025
Division of Microbiology, Tulane National Primate Research Center, Tulane University, Covington, LA 70433, United States.
This work aims to (1) identify microbial and metabolic alterations and (2) reveal a shift in phenylalanine production-consumption equilibrium in individuals with HIV. We conducted extensive searches in multiple databases [MEDLINE, Web of Science (including Cell Press, Oxford, HighWire, Science Direct, IOS Press, Springer Nature, PNAS, and Wiley), Google Scholar, and Embase] and selected two case-control 16S data sets (GenBank IDs: SRP039076 and EBI ID: ERP003611) for analysis. We assessed alpha and beta diversity, performed univariate tests on genus-level relative abundances, and identified significant microbiome features using random forest.
View Article and Find Full Text PDFDiscov Oncol
March 2025
Department of Hematology, Anqing Municipal Hospital, Anqing Hospital Affiliated to Anhui Medical University, Anqing, China.
Clinical management of acute myeloid leukemia (AML) poses significant challenges due to its poor prognosis and heterogeneous nature. Discovering new biomarkers is crucial for improving risk assessment and customizing treatment approaches. While leukocyte-specific transcript 1 (LST1) is implicated in inflammation and immune regulation, its function in AML remains ambiguous.
View Article and Find Full Text PDFBiometrics
January 2025
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States.
SARS-CoV-2-infected individuals have reported a diverse collection of persistent and often debilitating symptoms commonly referred to as long COVID or post-acute sequelae of SARS-CoV-2 (PASC). Identifying PASC and its subphenotypes is challenging because available data are "negative-unlabeled" as uninfected individuals must be PASC negative, but those with prior infection have unknown PASC status. Moreover, feature selection among many potentially informative characteristics can facilitate reaching a concise and easily interpretable PASC definition.
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