Background: Martorell hypertensive ischemic leg ulcer (HYTILU) is a chronic, hard-to-heal wound linked to hypertension. This study explores nanofat grafting as a regenerative alternative to traditional skin grafting for improved healing and patient outcomes.
Objective: To explore the efficacy of nanofat grafting in the management of HYTILU and compare it with skin grafting.
Materials And Methods: This was a retrospective single-center pilot study involving 23 patients with HYTILU treated with adipose-derived stromal cells (adipose-derived stromal cells/nanofat). The primary outcomes were ulcer healing rate, pain reduction, and improvements in quality of life, as measured by SCAR-Q (a scar quality of life questionnaire) and the Vancouver Scar Scale, over a period of 6 months posttreatment.
Results: This study revealed a significant decrease in ulcer size from an initial mean of 39.69 cm² to complete healing, with an average healing time of 4.65 months. The mean visual analog scale pain scores significantly decreased from an initial score of 5.87 to 0.39 at 3 months postinjection (P < .0001). Quality of life was significantly improved after treatment, as underscored by higher SCAR-Q scores and lower Vancouver scale scores, indicating better scar quality and minimal adverse effects.
Conclusion: These study results underscore nanofat grafting as a superior alternative to traditional skin grafting for HYTILU, offering advantages in terms of healing time, pain management, and patient quality of life. Further research is needed to confirm these findings and assess the use of nanofat in the management of other chronic wounds.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Perioperative Trends in Distress Among Cancer Patients: A Systematic Review and Meta-Analysis.
Cancer Med
March 2025
Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA.
Introduction: Distress is common among cancer patients, especially those undergoing surgery. However, no study has systematically analyzed distress trends in this population. The purpose of this study was to systematically review perioperative rates of distress, as well as differences across cancer types, in cancer patients undergoing surgical intervention.
View Article and Find Full Text PDFUnderstanding Personalized Dynamics in Eating Disorders: A Dynamic Time Warp Analysis.
Int J Eat Disord
March 2025
Rivierduinen Eating Disorders Ursula, Leiden, the Netherlands.
Objective: To enhance our understanding of the processes of change and the interaction of symptoms, we applied a relatively novel method known as Dynamic Time Warp to data from low-threshold internet-based interventions directed at decreasing eating disorder (ED) symptoms and increasing help-seeking.
Method: Utilizing data from the Featback study, we examined how various factors such as ED psychopathology, binge eating, vomiting, laxative use, BMI, anxiety, depression, self-efficacy, social support, well-being, and health-related quality of life interplayed over a period of 14 months among 355 individuals at six different time points. Moreover, we explored which symptoms exerted a significant temporal relationship on others (with high out-strength) and which were most affected by other symptoms (with high in-strength).
Evaluation of Nutritional Values of Defatted Black Soldier Fly (Hermetia illucens) Larvae Meal Using the Precision-Fed Cecectomized Rooster Assay.
J Anim Sci
March 2025
Department of Animal Sciences, University of Illinois, Urbana, IL 61801.
The use of insects, such as black soldier fly (Hermetia illucens) larvae meal (BSFLM), as an alternative protein source for pet food has gained attention due to their high nutritional value. The objective of this study was to determine the chemical composition, amino acid digestibility, and protein quality of defatted BSFLM of two distinct substrates (wheat and corn, BSFLM-W and BSFLM-C). Whole egg powder (WEP) and chicken meal (CM) were used as reference protein sources commonly used in pet foods.
View Article and Find Full Text PDFAmino Acid Digestibility of Yellow Mealworm-Based Ingredients using the Precision-Fed Cecectomized Rooster Assay.
J Anim Sci
March 2025
Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Yellow mealworms (Tenebrio molitor) serve as an alternative protein source. Because the amino acid (AA) concentrations, AA digestibility, and protein quality of ingredients may vary depending on their husbandry, harvest and processing procedures, and other factors, each should be evaluated separately. The objective of this study was to measure the AA composition, AA digestibility, and protein quality of yellow mealworm-based ingredients using the precision-fed cecectomized rooster assay.
View Article and Find Full Text PDFHemophilia is associated with accelerated biological aging.
Haematologica
March 2025
Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna; Vienna.
Hemophilia is a rare X-linked bleeding disorder caused by mutations in the F8 or F9 gene (hemophilia A or B), leading to deficient factor VIII or IX proteins, respectively. Hemophilia-related complications caused by bleeding into the joints (the hallmark of hemophilia) and age-related comorbidities occur frequently and impact the functionality and quality of life of persons with hemophilia (PwH). Given the chronic nature of hemophilia, we hypothesized that hemophilia has an association with accelerated biological aging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!